Yuan Dongfeng, Meng Yitong, Ai Zhongzhu, Zhou Shiquan
Faculty of Pharmacy, Hubei University of Chinese Medicine, Wuhan, China.
Hubei Shizhen Laboratory, Wuhan, China.
Front Neurosci. 2024 Jan 5;17:1289019. doi: 10.3389/fnins.2023.1289019. eCollection 2023.
With its high prevalence, depression's pathogenesis remains unclear. Recent attention has turned to the interplay between depression and epigenetic modifications. However, quantitative bibliometric analyses are lacking. This study aims to visually analyze depression epigenetics trends, utilizing bibliometric tools, while comprehensively reviewing its epigenetic mechanisms.
Utilizing the Web of Science core dataset, we collected depression and epigenetics-related studies. Employing VOSViewer software, we visualized data on authors, countries, journals, and keywords. A ranking table highlighted field leaders.
Analysis encompassed 3,469 depression epigenetics studies published from January 2002 to June 2023. Key findings include: (1) Gradual publication growth, peaking in 2021; (2) The United States and its research institutions leading contributions; (3) Need for enhanced collaborations, spanning international and interdisciplinary efforts; (4) Keyword clustering revealed five main themes-early-life stress, microRNA, genetics, DNA methylation, and histone acetylation-highlighting research hotspots; (5) Limited focus on adolescent depression epigenetics, warranting increased attention.
Taken together, this study revealed trends and hotspots in depression epigenetics research, underscoring global collaboration, interdisciplinary fusion, and multi-omics data's importance. It discussed in detail the potential of epigenetic mechanisms in depression diagnosis and treatment, advocating increased focus on adolescent research in this field. Insights aid researchers in shaping their investigative paths toward understanding depression's epigenetic mechanisms and antidepressant interventions.
抑郁症发病率高，但其发病机制仍不清楚。最近，人们的注意力转向了抑郁症与表观遗传修饰之间的相互作用。然而，缺乏定量的文献计量分析。本研究旨在利用文献计量工具直观分析抑郁症表观遗传学趋势，同时全面综述其表观遗传机制。
利用科学网核心数据集，我们收集了与抑郁症和表观遗传学相关的研究。使用VOSViewer软件，我们对作者、国家、期刊和关键词的数据进行了可视化。一个排名表突出了该领域的领军人物。
分析涵盖了2002年1月至2023年6月发表的3469项抑郁症表观遗传学研究。主要发现包括：（1）发表量逐渐增长，在2021年达到峰值；（2）美国及其研究机构贡献最大；（3）需要加强国际和跨学科的合作；（4）关键词聚类揭示了五个主要主题——早期生活压力、微小RNA、遗传学、DNA甲基化和组蛋白乙酰化——突出了研究热点；（5）对青少年抑郁症表观遗传学的关注有限，值得更多关注。
综上所述，本研究揭示了抑郁症表观遗传学研究的趋势和热点，强调了全球合作、跨学科融合以及多组学数据的重要性。详细讨论了表观遗传机制在抑郁症诊断和治疗中的潜力，主张增加对该领域青少年研究的关注。这些见解有助于研究人员规划其研究路径，以了解抑郁症的表观遗传机制和抗抑郁干预措施。
