Saedmocheshi Saber, Amiri Ehsan, Mehdipour Aref, Stefani Giuseppe Potrick
Department of Physical Education and Sport Sciences, Faculty of Humanities and Social Sciences, University of Kurdistan, Sanandaj 6617715175, Iran.
School of Health and Life Sciences, Pontifical Catholic University of Rio Grande do Sul, Porto Alegre 90619-900, Brazil.
Sports (Basel). 2024 Jan 13;12(1):32. doi: 10.3390/sports12010032.
Vitamin D is essential for the optimal health of the skeletal system. However, this vitamin also plays a role in other functions of the human body, such as muscle, immune, and inflammatory functions. Some studies have reported that adequate levels of vitamin D improve immune system function by reducing the levels of certain pro-inflammatory cytokines, which can protect against the risk of post-exercise illness. This systematic review aims to investigate the effects of vitamin D supplementation on pro-inflammatory cytokines in athletes. This study was conducted using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A literature search was conducted in SPORTDiscus, PubMed, ScienceDirect, and Google Scholar up to 1 October 2023. The quality of the articles was evaluated using the Risk of Bias 2 Tool. After searching the databases, a total of 7417 studies were identified, 6 of which met the eligibility criteria, and their outcomes were presented. The six studies included 176 participants. All six studies are randomized control trials, including a total of 176 subjects, primarily men (81%). Regarding the types of athletes, most participants were endurance athletes. Our investigation in this systematic review demonstrated that out of the six studies, only two of them reported significant changes in IL-6 and TNF-α levels after taking high-dose vitamin D. Other studies did not present any significant changes after vitamin D supplementation in athletes with respect to IL-6 and TNF-α levels. Further studies are needed to determine the effectiveness of vitamin D supplementation for athletes as a disease-prone community.
维生素D对骨骼系统的最佳健康至关重要。然而，这种维生素在人体的其他功能中也发挥着作用，如肌肉、免疫和炎症功能。一些研究报告称，充足的维生素D水平通过降低某些促炎细胞因子的水平来改善免疫系统功能，这可以预防运动后疾病的风险。本系统评价旨在研究补充维生素D对运动员促炎细胞因子的影响。本研究按照系统评价和Meta分析的首选报告项目（PRISMA）指南进行。截至2023年10月1日，在体育医学数据库（SPORTDiscus）、PubMed、科学Direct和谷歌学术上进行了文献检索。使用偏倚风险2工具评估文章的质量。在检索数据库后，共识别出7417项研究，其中6项符合纳入标准，并呈现了它们的结果。这六项研究包括176名参与者。所有六项研究均为随机对照试验，共包括176名受试者，主要为男性（81%）。关于运动员类型，大多数参与者是耐力运动员。我们在本系统评价中的调查表明，在这六项研究中，只有两项报告了服用高剂量维生素D后白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）水平有显著变化。其他研究表明，补充维生素D后，运动员的IL-6和TNF-α水平没有任何显著变化。作为一个易患病群体，需要进一步的研究来确定补充维生素D对运动员的有效性。
