Neumüller J, Gialamas J, Höger H, Partsch G, Eberl R, Adamiker D
Z Rheumatol. 1986 Nov-Dec;45(6):312-8.
The effect of superoxide dismutase (SOD) was studied in an experimental arthrosis model (fixation arthrosis in rabbits). Out of a total of 40 animals, 20 of which were to be treated with SOD and 20 with placebos, 5 animals each were given padded stiffened bandages to immobilize their right knee joints for 1 week, 2 weeks, 3 weeks and 4 weeks respectively. After removing the bandage and a two-week recovery period the SOD or placebo treatment respectively was begun. During this period the animals were allowed to move freely. In 20 animals 0.5 mg SOD in 0.2 ml of a 0.5% xylocaine solution were applied intraarticularly in both popliteal spaces once a week for a total of 4 weeks. 20 control animals likewise received 0.2 ml of a 0.5% xylocaine solution (placebo) in both popliteal spaces in the same time intervals. After treatment the animals were killed and examined. A further 5 animals were not given a stiffened bandage, but for 4 weeks they received intraarticular injections once a week of 0.2 ml of a 0.9% saline to act as controls. The evaluation of the changes in the joints was by histological examination and examination by scanning electron microscope. In comparison to the placebo treatment the SOD treatment in this animal experiment did not lead to a significant change in the arthrotic process.
在实验性关节病模型（兔关节固定性关节病）中研究了超氧化物歧化酶（SOD）的作用。总共40只动物，其中20只用SOD治疗，20只用安慰剂治疗，每组分别有5只动物被给予加垫的固定绷带，分别固定其右膝关节1周、2周、3周和4周。去除绷带并经过两周恢复期后，分别开始SOD或安慰剂治疗。在此期间，允许动物自由活动。对20只动物，在两侧腘窝关节腔内每周注射一次0.2ml含0.5mg SOD的0.5%利多卡因溶液，共注射4周。20只对照动物同样在相同时间间隔在两侧腘窝关节腔内注射0.2ml 0.5%利多卡因溶液（安慰剂）。治疗后处死动物并进行检查。另外5只动物未给予固定绷带，但在4周内每周接受一次关节腔内注射0.2ml 0.9%生理盐水作为对照。通过组织学检查和扫描电子显微镜检查对关节变化进行评估。在该动物实验中，与安慰剂治疗相比，SOD治疗未导致关节病进程发生显著变化。
