Liongue Clifford, Sobah Mohamed Luban, Ward Alister C
School of Medicine, Deakin University, Waurn Ponds, Geelong, VIC 3216, Australia.
Institute for Mental and Physical Health and Clinical Translation, Deakin University, Waurn Ponds, Geelong, VIC 3216, Australia.
Biomedicines. 2023 Dec 23;12(1):45. doi: 10.3390/biomedicines12010045.
The signal transducer and activator of transcription (STAT) family of proteins has been demonstrated to perform pivotal roles downstream of a myriad of cytokines, particularly those that control immune cell production and function. This is highlighted by both gain-of-function (GOF) and loss-of-function (LOF) mutations being implicated in various diseases impacting cells of the immune system. These mutations are typically inherited, although somatic GOF mutations are commonly observed in certain immune cell malignancies. This review details the growing appreciation of STAT proteins as a key node linking immunodeficiency, autoimmunity and cancer.
信号转导与转录激活因子（STAT）蛋白家族已被证明在众多细胞因子下游发挥关键作用，尤其是那些控制免疫细胞产生和功能的细胞因子。功能获得性（GOF）和功能丧失性（LOF）突变与影响免疫系统细胞的各种疾病有关，这突出了这一点。这些突变通常是遗传性的，尽管在某些免疫细胞恶性肿瘤中常见体细胞GOF突变。这篇综述详细阐述了人们越来越认识到STAT蛋白是连接免疫缺陷、自身免疫和癌症的关键节点。
