非霍奇金淋巴瘤细胞遗传学结果与组织病理学之间的关系。

Relationship between cytogenetic findings and histopathology in non-Hodgkin lymphoma.

作者信息

Kristoffersson U, Heim S, Olsson H, Akerman M, Mitelman F

出版信息

Acta Pathol Microbiol Immunol Scand A. 1987 Jan;95(1):1-5. doi: 10.1111/j.1699-0463.1987.tb00001_95a.x.

DOI:10.1111/j.1699-0463.1987.tb00001_95a.x

Abstract

The cytogenetic findings in 70 patients with non-Hodgkin lymphoma have been correlated with tumor histopathology according to the Kiel classification. Certain chromosome aberrations displayed a nonrandom association with the grade of malignancy: 4 lymphomas out of 6 with 1p+, 5 out of 7 with del(6)(q15), 7 out of 11 with 14q+, and 5 out of 8 with +18 belonged to the high grade malignancy group, whereas 9 lymphomas out of 10 with t(14;18) were low grade malignant. Two aberration types were closely associated with specific histopathologic subtypes: t(14;18) occurred in 7 cases out of 10 in centroblastic/centrocytic (cb/cc) follicular lymphomas, and 5 cases out of 6 with i(17q) were cb or cb/cc. Although less striking, there was a tendency for del(6)(q15) to occur in cb or cb/cc lymphomas (4 cases out of 7), in contrast to only 1 case out of 5 with the more distal deletion del(6)(q21).

摘要

根据基尔分类法，对70例非霍奇金淋巴瘤患者的细胞遗传学结果与肿瘤组织病理学进行了相关性分析。某些染色体畸变与恶性程度呈现非随机关联：6例伴有1p+的淋巴瘤中有4例、7例伴有del(6)(q15)的淋巴瘤中有5例、11例伴有14q+的淋巴瘤中有7例以及8例伴有+18的淋巴瘤中有5例属于高级别恶性肿瘤组，而10例伴有t(14;18)的淋巴瘤中有9例为低级别恶性。两种畸变类型与特定的组织病理学亚型密切相关：在中心母细胞/中心细胞（cb/cc）滤泡性淋巴瘤的10例中有7例出现t(14;18)，6例伴有i(17q)的淋巴瘤中有5例为cb或cb/cc。虽然不太明显，但del(6)(q15)倾向于出现在cb或cb/cc淋巴瘤中（7例中有4例），相比之下，5例伴有更远端缺失del(6)(q21)的淋巴瘤中只有1例。