Calapai Marco, Puzzo Luisa, Bova Giuseppe, Vecchio Daniele Alfio, Blandino Rosario, Barbagallo Alessia, Ammendolia Ilaria, Cardia Luigi, Calapai Fabrizio, Currò Mariaconcetta, Ficarra Giovanni, Esposito Emanuela, Trimarchi Fabio, Di Mauro Debora, Calapai Gioacchino, Mannucci Carmen
Breast Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Pain Therapy Unit, San Vincenzo Hospital, Azienda Sanitaria Provinciale Messina, 98039 Messina, Italy.
Life (Basel). 2024 Jan 2;14(1):77. doi: 10.3390/life14010077.
Chronic post-surgical pain is a condition persisting for not less than 3 months after surgical intervention. It is evaluated that 25-60% of women who underwent breast cancer excision suffer from post-mastectomy pain syndrome, and anxiety, depression, sleep disturbance, and catastrophizing. Physical activity can reduce the risk of chronic diseases and has a good impact on mood and cognitive function. The aim of this study was to estimate the influence of physical activity on the intensity of pain, depression, and anxiety in women who underwent mastectomy for breast cancer removal.
A prospective observational unicentric cohort study was performed. Patients were females who underwent unilateral or bilateral mastectomy. The Numerical Rating Scale (NRS) was used to measure pain intensity, Beck's Depression Inventory (BDI) for depression, and Generalized Anxiety Disorders-7 (GAD-7) for anxiety evaluation. Physical activity was assessed by the International Physical Activity Questionnaire (IPAQ). Interleukin (IL)-17, IL-1β, cortisol, adrenocorticotropic hormone (ACTH), and brain-derived neurotrophic factor (BDNF) were also evaluated in the blood of patients. All evaluations were assessed 3 and 6 months after the surgery.
Adequate physical activity reduced the intensity of pain, depression, and anxiety symptoms in women affected by post-mastectomy pain syndrome. Moreover, adequately active women showed a reduction in biomarkers of inflammation, cortisol, ACTH, and an increase of BDNF.
Our results suggest that physical activity can improve the quality of life, reduce the intensity of pain and inflammatory markers, and be useful in the reduction of associated anxiety and depression.
慢性术后疼痛是指手术干预后持续不少于3个月的一种病症。据评估，接受乳腺癌切除术的女性中有25% - 60%患有乳房切除术后疼痛综合征，并伴有焦虑、抑郁、睡眠障碍和灾难化思维。体育活动可以降低慢性病风险，并对情绪和认知功能产生良好影响。本研究的目的是评估体育活动对因乳腺癌切除而接受乳房切除术的女性的疼痛强度、抑郁和焦虑的影响。
进行了一项前瞻性观察性单中心队列研究。患者为接受单侧或双侧乳房切除术的女性。采用数字评定量表（NRS）测量疼痛强度，采用贝克抑郁量表（BDI）评估抑郁，采用广泛性焦虑障碍量表-7（GAD-7）评估焦虑。通过国际体力活动问卷（IPAQ）评估体育活动情况。还对患者血液中的白细胞介素（IL）-17、IL-1β、皮质醇、促肾上腺皮质激素（ACTH）和脑源性神经营养因子（BDNF）进行了评估。所有评估均在手术后3个月和6个月进行。
适当的体育活动降低了受乳房切除术后疼痛综合征影响的女性的疼痛强度、抑郁和焦虑症状。此外，体育活动充足的女性炎症生物标志物、皮质醇、ACTH水平降低，BDNF水平升高。
我们的结果表明，体育活动可以改善生活质量，降低疼痛强度和炎症标志物水平，并有助于减轻相关的焦虑和抑郁。
