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融合酶葡萄糖-6-磷酸脱氢酶::6-磷酸葡萄糖酸内酯酶（G6PD::6PGL）作为[具体疾病名称1]、[具体疾病名称2]和[具体疾病名称3]中的潜在药物靶点 。 需注意，原文中“in , , and.”处应补充具体疾病信息，以上译文为根据已有内容的完整翻译。

Fused Enzyme Glucose-6-Phosphate Dehydrogenase::6-Phosphogluconolactonase (G6PD::6PGL) as a Potential Drug Target in , , and .

作者信息

Morales-Luna Laura, Vázquez-Bautista Montserrat, Martínez-Rosas Víctor, Rojas-Alarcón Miriam Abigail, Ortega-Cuellar Daniel, González-Valdez Abigail, Pérez de la Cruz Verónica, Arreguin-Espinosa Roberto, Rodríguez-Bustamante Eduardo, Rodríguez-Flores Eden, Hernández-Ochoa Beatriz, Gómez-Manzo Saúl

机构信息

Laboratorio de Bioquímica Genética, Instituto Nacional de Pediatría, Secretaría de Salud, Mexico City 04530, Mexico.

Posgrado en Ciencias Biológicas, Universidad Nacional Autónoma de México, Mexico City 04510, Mexico.

出版信息

Microorganisms. 2024 Jan 5;12(1):112. doi: 10.3390/microorganisms12010112.

DOI:10.3390/microorganisms12010112
PMID:38257939
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10819308/
Abstract

Several microaerophilic parasites such as , , and are major disease-causing organisms and are responsible for spreading infections worldwide. Despite significant progress made in understanding the metabolism and molecular biology of microaerophilic parasites, chemotherapeutic treatment to control it has seen limited progress. A current proposed strategy for drug discovery against parasitic diseases is the identification of essential key enzymes of metabolic pathways associated with the parasite's survival. In these organisms, glucose-6-phosphate dehydrogenase::6-phosphogluconolactonase (G6PD:: 6PGL), the first enzyme of the pentose phosphate pathway (PPP), is essential for its metabolism. Since G6PD:: 6PGL provides substrates for nucleotides synthesis and NADPH as a source of reducing equivalents, it could be considered an anti-parasite drug target. This review analyzes the anaerobic energy metabolism of , , and , with a focus on glucose metabolism through the pentose phosphate pathway and the significance of the fused G6PD:: 6PGL enzyme as a therapeutic target in the search for new drugs.

摘要

几种微需氧寄生虫，如[具体寄生虫名称1]、[具体寄生虫名称2]和[具体寄生虫名称3]，是主要的致病生物，在全球范围内传播感染。尽管在了解微需氧寄生虫的代谢和分子生物学方面取得了重大进展，但控制其感染的化疗治疗进展有限。目前针对寄生虫病药物研发提出的一种策略是鉴定与寄生虫生存相关的代谢途径中的关键必需酶。在这些生物中，磷酸戊糖途径（PPP）的首个酶葡萄糖-6-磷酸脱氢酶::6-磷酸葡萄糖酸内酯酶（G6PD::6PGL）对其代谢至关重要。由于G6PD::6PGL为核苷酸合成提供底物，并作为还原当量来源提供NADPH，因此它可被视为一种抗寄生虫药物靶点。本综述分析了[具体寄生虫名称1]、[具体寄生虫名称2]和[具体寄生虫名称3]的无氧能量代谢，重点关注通过磷酸戊糖途径的葡萄糖代谢以及融合的G6PD::6PGL酶作为寻找新药的治疗靶点的意义。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/f55200a93aaa/microorganisms-12-00112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a58917f41f87/microorganisms-12-00112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a2645aef19b5/microorganisms-12-00112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/6fd93d00327f/microorganisms-12-00112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a41e8af9680b/microorganisms-12-00112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/0b073ad599ed/microorganisms-12-00112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/f55200a93aaa/microorganisms-12-00112-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a58917f41f87/microorganisms-12-00112-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a2645aef19b5/microorganisms-12-00112-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/6fd93d00327f/microorganisms-12-00112-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/a41e8af9680b/microorganisms-12-00112-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/0b073ad599ed/microorganisms-12-00112-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/62de/10819308/f55200a93aaa/microorganisms-12-00112-g006.jpg

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