Denniss A R, Richards D A, Cody D V, Russell P A, Young A A, Ross D L, Uther J B
Am J Cardiol. 1987 Mar 1;59(6):586-90. doi: 10.1016/0002-9149(87)91174-x.
This study examined the incidence of delayed ventricular activation on signal-averaged electrocardiograms and the incidence of inducible sustained ventricular tachycardia (VT) at programmed stimulation (1 or 2 extrastimuli) in patients with and patients without spontaneous ventricular tachyarrhythmias. The correlation between delayed ventricular activation and inducible VT was investigated in 371 patients with acute myocardial infarction (AMI). In 32 patients with no ventricular disease and no spontaneous arrhythmias (group I), ventricular activation time averaged 115 +/- 2 ms, compared with 166 +/- 3 ms (p less than 0.001) for 65 patients with spontaneous ventricular tachyarrhythmias late after AMI (group II). In AMI patients with no spontaneous arrhythmias, ventricular activation time averaged 133 +/- 2 ms for 306 patients studied 1 to 4 weeks after AMI (group III) and 130 +/- 2 ms for 67 patients studied 3 to 12 months after AMI (group IV). The values for group III and group IV patients were each significantly higher than for group I (p less than 0.001), but lower than that for group II (p less than 0.001). The incidence of delayed ventricular activation was 89% for group II, 26% for group III and 18% for group IV. Sustained VT was not inducible in group I patients, but was inducible in 78% of group II (p less than 0.001 vs group I) and 20% of group III (p less than 0.05 vs group I; p less than 0.001 vs group II) (group IV was not studied).(ABSTRACT TRUNCATED AT 250 WORDS)
本研究检测了有或无自发性室性快速心律失常患者的信号平均心电图上延迟心室激动的发生率以及程序刺激（1次或2次额外刺激）时可诱发的持续性室性心动过速（VT）的发生率。在371例急性心肌梗死（AMI）患者中研究了延迟心室激动与可诱发VT之间的相关性。在32例无室性疾病且无自发性心律失常的患者（I组）中，心室激动时间平均为115±2毫秒，而在AMI后晚期出现自发性室性快速心律失常的65例患者（II组）中，心室激动时间平均为166±3毫秒（p<0.001）。在无自发性心律失常的AMI患者中，AMI后1至4周接受研究的306例患者（III组）心室激动时间平均为133±2毫秒，AMI后3至12个月接受研究的67例患者（IV组）心室激动时间平均为130±2毫秒。III组和IV组患者的值均显著高于I组（p<0.001），但低于II组（p<0.001）。II组延迟心室激动的发生率为89%，III组为26%，IV组为18%。I组患者不能诱发持续性VT，但II组78%的患者可诱发（与I组相比，p<0.001），III组20%的患者可诱发（与I组相比，p<0.05；与II组相比，p<0.001）（未对IV组进行研究）。（摘要截短至250字）
