Universidade Federal de São Paulo, Escola Paulista de Medicina, Departamento de Medicina, São Paulo, SP, Brazil.
J Bras Nefrol. 2024 Apr-Jun;46(2):e20230117. doi: 10.1590/2175-8239-JBN-2023-0117en.
Chronic kidney disease is usually asymptomatic, and its diagnosis depends on laboratory tests, with emphasis on serum creatinine and proteinuria.
To assess knowledge on the role of serum creatinine as a biomarker of kidney function in a sample of the Brazilian population.
Cross-sectional observational study conducted in São Paulo (SP, Brazil), in which a random adult population was interviewed.
A total of 1138 subjects were interviewed, with a median age of 36 years old (27-52); 55.1% were female. Regarding the "creatinine" biomarker, 40.6% stated they had never performed such a test. When asked about their knowledge on the usefulness of this exam, only 19.6% knew its function. The other responses were "I don't know" (71.6%), evaluating heart function (0.9%) and liver function (7.8%). Of those who reported they had already taken a creatinine test, only 29.4% correctly identified the role of creatinine. When dividing the groups into "knows" and "does not know" the function of creatinine, a statistically significant difference (p < 0.05) was observed regarding level of education, female sex, being a healthcare student/worker, having ever measured creatinine, knowing someone with kidney disease and older age. In the multivariate analysis, the main variable related to knowing the creatinine role was having previously taken the test (OR 5.16; 95% CI 3.16-8.43, p < 0.001).
There is a significant lack of knowledge about creatinine and its use in checkups. The results indicate that greater efforts are needed from healthcare professionals to raise awareness on the role of serum creatinine.
慢性肾脏病通常无症状，其诊断依赖于实验室检查，重点是血清肌酐和蛋白尿。
评估巴西人群样本中血清肌酐作为肾功能生物标志物的知识。
在巴西圣保罗（SP）进行的横断面观察性研究，对随机成年人群进行了访谈。
共访谈了 1138 名受试者，中位数年龄为 36 岁（27-52）；55.1%为女性。关于“肌酐”生物标志物，40.6%的人表示从未进行过此类检测。当被问及他们对该检查的用途的了解时，只有 19.6%的人知道其功能。其他回答是“我不知道”（71.6%），评估心脏功能（0.9%）和肝脏功能（7.8%）。那些报告已经进行了肌酐检测的人中，只有 29.4%正确识别了肌酐的作用。将组分为“知道”和“不知道”肌酐的功能时，在教育水平、女性、曾接受过肌酐检测、知道有人患有肾病和年龄较大等方面存在统计学差异（p<0.05）。在多变量分析中，与了解肌酐作用相关的主要变量是之前进行过检测（OR 5.16；95%CI 3.16-8.43，p<0.001）。
对肌酐及其在检查中的用途存在明显的知识匮乏。结果表明，卫生保健专业人员需要做出更大的努力来提高对血清肌酐作用的认识。
