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Getting the Timing Right: Controlling BCL-2 Inhibition as an Antifibrotic Therapy.

作者信息

Cooley Joseph C, Redente Elizabeth F

机构信息

Department of Medicine National Jewish Health Denver, Colorado.

Department of Medicine University of Colorado School of Medicine Aurora, Colorado.

出版信息

Am J Respir Cell Mol Biol. 2024 Apr;70(4):231-232. doi: 10.1165/rcmb.2023-0436ED.

DOI:10.1165/rcmb.2023-0436ED
PMID:38259233
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11478124/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9d4/11478124/d6af34748589/rcmb.2023-0436EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9d4/11478124/d6af34748589/rcmb.2023-0436EDf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c9d4/11478124/d6af34748589/rcmb.2023-0436EDf1.jpg

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本文引用的文献

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Diagnoses and treatments for participants with interstitial lung abnormalities detected in the Yorkshire Lung Screening Trial.在约克郡肺部筛查试验中发现有间质性肺异常的参与者的诊断和治疗。
BMJ Open Respir Res. 2023 Aug;10(1). doi: 10.1136/bmjresp-2022-001490.
3
Interstitial lung abnormalities in a large clinical lung cancer screening cohort: association with mortality and ILD diagnosis.
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Respir Res. 2023 Feb 14;24(1):49. doi: 10.1186/s12931-023-02359-9.
4
Inhibition of antiapoptotic BCL-2 proteins with ABT-263 induces fibroblast apoptosis, reversing persistent pulmonary fibrosis.ABT-263 通过抑制抗凋亡 BCL-2 蛋白诱导成纤维细胞凋亡，从而逆转持续性肺纤维化。
JCI Insight. 2023 Feb 8;8(3):e163762. doi: 10.1172/jci.insight.163762.
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Challenges for Clinical Drug Development in Pulmonary Fibrosis.肺纤维化临床药物研发面临的挑战
Front Pharmacol. 2022 Jan 31;13:823085. doi: 10.3389/fphar.2022.823085. eCollection 2022.
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