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Editorial: Thymic function at single cell resolution.

作者信息

Laan Martti, Giraud Matthieu, Irla Magali

机构信息

Molecular Pathology, Department of Biomedicine, Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.

INSERM, Nantes Université, Center for Research in Transplantation and Translational Immunology, UMR 1064, Nantes, France.

出版信息

Front Immunol. 2024 Jan 8;14:1358957. doi: 10.3389/fimmu.2023.1358957. eCollection 2023.

DOI:10.3389/fimmu.2023.1358957
PMID:38259446
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10801162/
Abstract
摘要

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Editorial: Thymic function at single cell resolution.社论:单细胞分辨率下的胸腺功能
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Ephrin-B-dependent thymic epithelial cell-thymocyte interactions are necessary for correct T cell differentiation and thymus histology organization: relevance for thymic cortex development.Ephrin-B 依赖性胸腺上皮细胞-胸腺细胞相互作用对于正确的 T 细胞分化和胸腺组织学结构的组织至关重要:与胸腺皮质发育有关。
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The thymus gland: a target organ for growth hormone.胸腺:生长激素的靶器官。
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Gender Disparity Impacts on Thymus Aging and LHRH Receptor Antagonist-Induced Thymic Reconstitution Following Chemotherapeutic Damage.性别差异对化疗损伤后胸腺衰老和 LHRH 受体拮抗剂诱导的胸腺重建的影响。
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引用本文的文献

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Enigmatic thymus: Variations in anatomical localisation of thymic tissue as an easily misdiagnosed congenital anomaly in surgical practice.神秘的胸腺:胸腺组织解剖定位的变异,一种在外科实践中易被误诊的先天性异常。
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本文引用的文献

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Thymic epithelial cells co-opt lineage-defining transcription factors to eliminate autoreactive T cells.胸腺上皮细胞会利用谱系定义转录因子来清除自身反应性 T 细胞。
Cell. 2022 Jul 7;185(14):2542-2558.e18. doi: 10.1016/j.cell.2022.05.018. Epub 2022 Jun 16.
2
Instructive Cues of Thymic T Cell Selection.胸腺 T 细胞选择的指示线索。
Annu Rev Immunol. 2022 Apr 26;40:95-119. doi: 10.1146/annurev-immunol-101320-022432.
3
When the Damage Is Done: Injury and Repair in Thymus Function.当损伤发生时:胸腺功能的损伤与修复。
Front Immunol. 2020 Aug 12;11:1745. doi: 10.3389/fimmu.2020.01745. eCollection 2020.
4
A cell atlas of human thymic development defines T cell repertoire formation.人类胸腺发育的细胞图谱定义了 T 细胞库的形成。
Science. 2020 Feb 21;367(6480). doi: 10.1126/science.aay3224.
5
Thymic epithelial cell heterogeneity: TEC by TEC.胸腺上皮细胞异质性:TEC 到 TEC。
Nat Rev Immunol. 2020 Apr;20(4):239-253. doi: 10.1038/s41577-019-0238-0. Epub 2019 Dec 5.
6
A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation.胸腺器官发生的单细胞转录组图谱解析细胞类型和发育成熟。
Immunity. 2018 Jun 19;48(6):1258-1270.e6. doi: 10.1016/j.immuni.2018.04.015. Epub 2018 Jun 5.
7
Administration of RANKL boosts thymic regeneration upon bone marrow transplantation.RANKL 的给药可促进骨髓移植后的胸腺再生。
EMBO Mol Med. 2017 Jun;9(6):835-851. doi: 10.15252/emmm.201607176.
8
Clonal analysis reveals a common progenitor for thymic cortical and medullary epithelium.克隆分析揭示了胸腺皮质和髓质上皮细胞的共同祖细胞。
Nature. 2006 Jun 22;441(7096):988-91. doi: 10.1038/nature04813.
9
Medullary epithelial cells of the human thymus express a highly diverse selection of tissue-specific genes colocalized in chromosomal clusters.人类胸腺的髓质上皮细胞表达多种高度多样化的组织特异性基因,这些基因共定位于染色体簇中。
J Exp Med. 2004 Jan 19;199(2):155-66. doi: 10.1084/jem.20031677.