食用蜂王浆对缺血性中风患者中风后并发症的影响：一项随机对照试验的结果

Effects of the royal jelly consumption on post-stroke complications in patients with ischemic stroke: results of a randomized controlled trial.

作者信息

Karimi Elham, Arab Arman, Sepidarkish Mahdi, Khorvash Fariborz, Saadatnia Mohammad, Amani Reza

机构信息

Department of Clinical Nutrition, School of Nutrition and Food Sciences, Isfahan University of Medical Sciences, Isfahan, Iran.

Research Development Center, Arash Women's Hospital, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

Front Nutr. 2024 Jan 8;10:1227414. doi: 10.3389/fnut.2023.1227414. eCollection 2023.

DOI:10.3389/fnut.2023.1227414

PMID:38260068

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10800663/

Abstract

AIMS

There is a paucity of evidence regarding the benefit of royal jelly (RJ) on post-stroke complications in patients with ischemic stroke. To address this knowledge gap, this randomized, triple-blind, placebo-controlled clinical trial was carried out to determine the effects of RJ consumption on post-stroke clinical outcomes.

METHODS

Of 64 eligible ischemic stroke patients (45-80 years), 32 were randomized to the RJ and 32 to the placebo groups and completed a 12-week intervention. The intervention group was advised to receive 1,000 mg of RJ dragee daily after breakfast. Post-stroke complications including cognition, fatigue, mental health, and appetite, along with serum levels of brain-derived neurotrophic factor (BDNF), and mid-upper arm circumference (MUAC) were assessed in groups pre-and post-intervention.

RESULTS

After 12 weeks of RJ consumption, cognitive function [adjusted mean difference, 4.71; 95% confidence interval (CI), 1.75 to 7.67], serum levels of BDNF (adjusted mean difference, 0.36; 95% CI, 0.05 to 0.67), stress (adjusted mean difference, -3.33; 95% CI, -6.50 to -0.17), and appetite (adjusted mean difference, 1.38; 95% CI, 0.19 to 2.56) were significantly improved. However, the findings for fatigue (adjusted mean difference, -4.32; 95% CI, -10.28 to 1.63), depression (adjusted mean difference, -1.71; 95% CI, -5.58 to 2.16), anxiety (adjusted mean difference, -2.50; 95% CI, -5.50 to 0.49), and MUAC (adjusted mean difference, 0.36; 95% CI, -0.11 to 0.84) were less favorable.

CONCLUSION

Findings support the benefits of RJ consumption in improving post-stroke complications and clinical outcomes.: https://www.irct.ir/trial/59275, Identifier IRCT20180818040827N4.

摘要

目的

关于蜂王浆（RJ）对缺血性中风患者中风后并发症益处的证据不足。为填补这一知识空白，开展了这项随机、三盲、安慰剂对照临床试验，以确定食用RJ对中风后临床结局的影响。

方法

在64名符合条件的缺血性中风患者（45 - 80岁）中，32名被随机分配到RJ组，32名被分配到安慰剂组，并完成了为期12周的干预。干预组被建议在早餐后每天服用1000毫克RJ糖衣丸。在干预前后对两组患者进行评估，包括中风后并发症，如认知、疲劳、心理健康和食欲，以及血清脑源性神经营养因子（BDNF）水平和上臂中部周长（MUAC）。

结果

食用RJ 12周后，认知功能[调整后平均差异，4.71；95%置信区间（CI），1.75至7.67]、血清BDNF水平（调整后平均差异，0.36；95%CI，0.05至0.67）、压力（调整后平均差异，-3.33；95%CI，-6.50至-0.17）和食欲（调整后平均差异，1.38；95%CI，0.19至2.56）均有显著改善。然而，疲劳（调整后平均差异，-4.32；95%CI，-10.28至1.63）、抑郁（调整后平均差异，-1.71；95%CI，-5.58至2.16）、焦虑（调整后平均差异，-2.50；95%CI，-5.50至0.49）和MUAC（调整后平均差异，0.36；95%CI，-0.11至0.84）的结果则不太理想。