Johns D R, Gress D R
Am J Med. 1987 Mar;82(3):560-2. doi: 10.1016/0002-9343(87)90463-3.
A previously healthy patient became acutely encephalopathic, with complete disorientation and amnesia, several days after the onset of thoracic herpes zoster. She had transiently abnormal electroencephalographic results, abnormalities on radionuclide brain scanning, and cerebrospinal fluid pleocytosis. There was no evidence of a toxic/metabolic encephalopathy except for a mildly elevated ammonia level. Intravenously administered acyclovir (30 mg/kg per day) induced a dramatic response, with complete resolution of the encephalopathy within 72 hours and normalization of the electroencephalographic results. The scant clinical experience with the successful use of acyclovir in the treatment of herpes zoster-associated encephalitis is reviewed.
一名既往健康的患者在胸段带状疱疹发作几天后出现急性脑病，表现为完全定向障碍和失忆。她的脑电图结果短暂异常，放射性核素脑扫描有异常，脑脊液淋巴细胞增多。除氨水平轻度升高外，没有中毒/代谢性脑病的证据。静脉注射阿昔洛韦（每天30mg/kg）引起显著反应，脑病在72小时内完全消退，脑电图结果恢复正常。本文综述了成功使用阿昔洛韦治疗带状疱疹相关性脑炎的有限临床经验。
