重复性手指刺激后脑卒中幸存者静息态脑活动的改变。
Alteration in Resting-State Brain Activity in Stroke Survivors After Repetitive Finger Stimulation.
机构信息
From the University of Oklahoma Health Sciences Center, College of Medicine, Oklahoma City, Oklahoma (DH); University of Oklahoma, Stephenson School of Biomedical Engineering, Norman, Oklahoma (WAS); University of Oklahoma Health Sciences Center, Hudson College of Public Health, Oklahoma City, Oklahoma (SAJ); Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois (JNW, YY); Department of Rehabilitation Sciences, University of Oklahoma Health Sciences Center, Tulsa, Oklahoma (LVL, CFC, YY); Department of Neurology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma (ES); Department of Physical Medicine and Rehabilitation, UT Health Huston McGovern Medical School, Houston, Texas (SL); Clinical Imaging Research Center, Stephenson Family Clinical Research Institute, Carle Foundation Hospital, Urbana, Illinois (YY); Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois (YY); and Department of Physical Therapy and Human Movement Sciences, Northwestern University, Chicago, Illinois (YY).
出版信息
Am J Phys Med Rehabil. 2024 May 1;103(5):395-400. doi: 10.1097/PHM.0000000000002393. Epub 2024 Jan 12.
OBJECTIVE
This quasi-experimental study examined the effect of repetitive finger stimulation on brain activation in eight stroke and seven control subjects, measured by quantitative electroencephalogram.
METHODS
We applied 5 mins of 2-Hz repetitive bilateral index finger transcutaneous electrical nerve stimulation and compared differences pre- and post-transcutaneous electrical nerve stimulation using quantitative electroencephalogram metrics delta/alpha ratio and delta-theta/alpha-beta ratio.
RESULTS
Between-group differences before and after stimulation were significantly different in the delta/alpha ratio ( z = -2.88, P = 0.0040) and the delta-theta/alpha-beta ratio variables ( z = -3.90 with P < 0.0001). Significant decrease in the delta/alpha ratio and delta-theta/alpha-beta ratio variables after the transcutaneous electrical nerve stimulation was detected only in the stroke group (delta/alpha ratio diff = 3.87, P = 0.0211) (delta-theta/alpha-beta ratio diff = 1.19, P = 0.0074).
CONCLUSIONS
The decrease in quantitative electroencephalogram metrics in the stroke group may indicate improved brain activity after transcutaneous electrical nerve stimulation. This finding may pave the way for a future novel therapy based on transcutaneous electrical nerve stimulation and quantitative electroencephalogram measures to improve brain recovery after stroke.
目的
本准实验研究通过定量脑电图测量，考察了 8 例脑卒中患者和 7 例对照者接受 2 Hz 重复双侧食指经皮神经电刺激后的大脑激活情况。
方法
我们应用 5 分钟的 2 Hz 重复双侧食指经皮神经电刺激，并使用定量脑电图指标 delta/alpha 比和 delta-theta/alpha-beta 比比较刺激前后的差异。
结果
刺激前后两组间 delta/alpha 比（ z = -2.88，P = 0.0040）和 delta-theta/alpha-beta 比变量（ z = -3.90，P < 0.0001）存在显著差异。仅在脑卒中组中检测到经皮神经电刺激后 delta/alpha 比和 delta-theta/alpha-beta 比变量显著降低（delta/alpha 比差= 3.87，P = 0.0211）（delta-theta/alpha-beta 比差= 1.19，P = 0.0074）。
结论
脑卒中组定量脑电图指标的降低可能表明经皮神经电刺激后大脑活动得到改善。这一发现可能为未来基于经皮神经电刺激和定量脑电图测量的新型治疗方法铺平道路，以改善脑卒中后的大脑恢复。
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