Chen Peiming, Liu Tai-Wa, Kwong Patrick W H, Lai Claudia K Y, Chung Raymond C K, Tsoh Joshua, Ng Shamay S M
Department of Rehabilitation Sciences (P.C., P.W.H.K., R.C.K.C., S.S.M.N.), The Hong Kong Polytechnic University, China.
School of Nursing & Health Studies, Hong Kong Metropolitan University, Ho Man Tin, China (T.-W.L.).
Stroke. 2022 Apr;53(4):1134-1140. doi: 10.1161/STROKEAHA.121.036895. Epub 2021 Dec 2.
Recent evidence has shown bilateral transcutaneous electrical nerve stimulation (Bi-TENS) combined with task-oriented training (TOT) to be superior to unilateral transcutaneous electrical nerve stimulation (Uni-TENS)+TOT in improving lower limb motor functioning following stroke. However, no research explored the effect of Bi-TENS+TOT in improving upper limb motor recovery. This study aimed to compare Bi-TENS+TOT with Uni-TENS+TOT, Placebo transcutaneous electrical nerve stimulation (Placebo-TENS)+TOT, and no treatment (Control) groups in upper limb motor recovery.
This is a 4-group parallel design. One hundred and twenty subjects were given either Bi-TENS+TOT, Uni-TENS+TOT, Placebo-TENS+TOT, or Control without treatment in this randomized controlled trial. Twenty 60-minute sessions were administered 3× per week for 7 weeks. The outcome measure was the Fugl-Meyer Assessment of Upper Extremity, which was assessed at baseline, after 10 sessions (mid-intervention) and 20 sessions (post-intervention) of intervention, and at 1- and 3-month follow-up.
Patients in the Bi-TENS+TOT group showed greater improvement in the Fugl-Meyer Assessment of Upper Extremity scores than Uni-TENS+TOT (mean difference, 2.13; =0.004), Placebo-TENS+TOT (mean difference, 2.63; <0.001), and Control groups (mean difference, 3.11; <0.001) at post-intervention. Both Bi-TENS+TOT (mean difference, 3.39; <0.001) and Uni-TENS+TOT (mean difference, 1.26; =0.018) showed significant within-group improvement in the Fugl-Meyer Assessment of Upper Extremity scores. Patients in the Bi-TENS+TOT group showed earlier within-group improvement in the Fugl-Meyer Assessment of Upper Extremity scores at mid-intervention than Uni-TENS+TOT. These improvements were maintained at the 3-month follow-up assessment.
Bi-TENS combined with TOT is an effective therapy for improving upper limb motor recovery following stroke.
URL: https://www.
gov; Unique identifier: NCT03112473.
最近的证据表明，双侧经皮电刺激神经疗法（Bi-TENS）联合任务导向训练（TOT）在改善中风后下肢运动功能方面优于单侧经皮电刺激神经疗法（Uni-TENS）+TOT。然而，尚无研究探讨Bi-TENS+TOT对改善上肢运动恢复的效果。本研究旨在比较Bi-TENS+TOT与Uni-TENS+TOT、安慰剂经皮电刺激神经疗法（Placebo-TENS）+TOT以及无治疗（对照组）在上肢运动恢复方面的效果。
这是一项4组平行设计。在这项随机对照试验中，120名受试者分别接受Bi-TENS+TOT、Uni-TENS+TOT、Placebo-TENS+TOT或不进行治疗的对照。每周进行3次，每次60分钟，共进行7周。结局指标是上肢Fugl-Meyer评估，在基线、干预10次（干预中期）和20次（干预后）以及1个月和3个月随访时进行评估。
在干预后，Bi-TENS+TOT组患者在上肢Fugl-Meyer评估得分上的改善程度大于Uni-TENS+TOT组（平均差异为2.13；P=0.004）、Placebo-TENS+TOT组（平均差异为2.63；P<0.001）和对照组（平均差异为3.11；P<0.001）。Bi-TENS+TOT组（平均差异为3.39；P<0.001）和Uni-TENS+TOT组（平均差异为1.26；P=0.018）在上肢Fugl-Meyer评估得分上均显示出显著的组内改善。在干预中期，Bi-TENS+TOT组患者在上肢Fugl-Meyer评估得分上的组内改善比Uni-TENS+TOT组更早。这些改善在3个月随访评估时得以维持。
Bi-TENS联合TOT是改善中风后上肢运动恢复的有效疗法。
网址：https://www.
gov；唯一标识符：NCT03112473。
