上呼吸道与下呼吸道在经鼻腔接种或气溶胶暴露后 SARS-CoV-2 的分隔复制。
Compartmentalized SARS-CoV-2 Replication in the Upper vs Lower Respiratory Tract After Intranasal Inoculation or Aerosol Exposure.
机构信息
Laboratory of Virology.
Rocky Mountain Veterinary Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana.
出版信息
J Infect Dis. 2024 Sep 23;230(3):657-661. doi: 10.1093/infdis/jiae018.
Nonhuman primate models are essential for the development of vaccines and antivirals against infectious diseases. Rhesus macaques are a widely utilized infection model for SARS-CoV-2. We compared cellular tropism and virus replication in rhesus macaques inoculated with SARS-CoV-2 via the intranasal route or via exposure to aerosols. Intranasal inoculation resulted in replication in the upper respiratory tract with limited involvement in the lower respiratory tract, whereas exposure to aerosols resulted in infection throughout the respiratory tract. In comparison with multiroute inoculation, intranasal and aerosol inoculation resulted in reduced SARS-CoV-2 replication in the respiratory tract.
非人类灵长类动物模型对于开发针对传染病的疫苗和抗病毒药物至关重要。恒河猴是用于 SARS-CoV-2 的广泛应用的感染模型。我们比较了经鼻腔途径或暴露于气溶胶途径接种 SARS-CoV-2 的恒河猴中的细胞嗜性和病毒复制。鼻腔接种导致上呼吸道复制，而下呼吸道受累有限，而暴露于气溶胶则导致整个呼吸道感染。与多途径接种相比，鼻腔和气溶胶接种导致呼吸道中 SARS-CoV-2 复制减少。
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