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使用仿生人类鼻腔模型可视化鼻用粉剂分布情况。

Visualization of nasal powder distribution using biomimetic human nasal cavity model.

作者信息

Su Jiawen, Liu Yan, Sun Hongyu, Naeem Abid, Xu Huipeng, Qu Yue, Wang Caifen, Li Zeru, Lu Jianhua, Wang Lulu, Wang Xiaofeng, Wu Jie, Sun Lixin, Zhang Jiwen, Wang Zhigang, Yang Rui, Wu Li

机构信息

Key Laboratory of Modern Preparation of TCM, Ministry of Education, Jiangxi University of Chinese Medicine, Nanchang 330004, China.

Yangtze Delta Drug Advanced Research Institute, Nantong 226126, China.

出版信息

Acta Pharm Sin B. 2024 Jan;14(1):392-404. doi: 10.1016/j.apsb.2023.06.007. Epub 2023 Jun 13.

DOI:10.1016/j.apsb.2023.06.007
PMID:38261815
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10792963/
Abstract

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal cavity. However, no reliable method is currently available to assess its impact on delivery performance. In this study, a biomimetic nasal model based on three-dimensional (3D) reconstruction and three-dimensional printing (3DP) technology was developed for visualizing the deposition of drug powders in the nasal cavity. The results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and females. The nasal cavity model was modified with dimethicone and validated to be suitable for the deposition test. The experimental device produced the most satisfactory results with five spray times. Furthermore, particle sizes and spray angles were found to significantly affect the experimental device's performance and alter drug distribution, respectively. Additionally, mometasone furoate (MF) nasal spray (NS) distribution patterns were investigated in a goat nasal cavity model and three male goat noses, confirming the and correlation. In conclusion, the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

摘要

鼻腔给药效率高度依赖于药物在鼻腔内的沉积位置。然而，目前尚无可靠的方法来评估其对给药性能的影响。在本研究中，基于三维（3D）重建和三维打印（3DP）技术开发了一种仿生鼻腔模型，用于可视化药物粉末在鼻腔内的沉积情况。结果显示，中国男性和女性仿生鼻腔模型前部的腔面积、体积和粉末分布存在显著差异。用二甲基硅油对鼻腔模型进行了改良，并验证其适用于沉积测试。该实验装置在喷雾五次时产生了最满意的结果。此外，发现粒径和喷雾角度分别显著影响实验装置的性能和改变药物分布。此外，在山羊鼻腔模型和三只雄性山羊的鼻子中研究了糠酸莫米松（MF）鼻喷雾剂（NS）的分布模式，证实了两者之间的相关性。总之，所开发的人体鼻腔结构仿生装置有潜力成为评估鼻腔给药系统沉积和分布的有价值工具。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/364501211b35/gr12.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/d6864f69d4d7/gr4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/be6fcab46891/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/364501211b35/gr12.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/58be5c210c8a/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/0d9b461488fb/sc1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/72361094f696/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/18f74d599e13/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/5fac23198130/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/d6864f69d4d7/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/49592de15db2/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/9288911c6c67/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/e9e16e17f003/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/4d25c64c6d72/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/a4ffbbd88ed2/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/2f52b7f904e3/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/be6fcab46891/gr11.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3fab/10792963/364501211b35/gr12.jpg

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