Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
Beijing Key Laboratory for HIV/AIDS Research, Clinical and Research Center for Infectious Diseases, Beijing Institute of Hepatology, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China.
J Neurol Sci. 2024 Feb 15;457:122889. doi: 10.1016/j.jns.2024.122889. Epub 2024 Jan 18.
HIV-associated neurocognitive disorder (HAND) has become a chronic neurodegenerative disease affecting the quality of life in people living with HIV (PLWH). Despite an established association between HAND and neuroinflammation induced by HIV proteins (gp120, Tat, Rev., Nef, and Vpr), the pathogenesis of HAND remains to be fully elucidated. Accumulating evidence demonstrated that the gut microbiome is emerging as a critical regulator of various neurodegenerative diseases (e.g., Parkinson's disease, Alzheimer's disease), suggesting that the crosstalk between the gut microbiome and neuroinflammation may contribute to the development of these diseases, for example, gut dysbiosis and microbiota-derived metabolites can trigger inflammation in the brain. However, the potential role of the gut microbiome in the pathogenesis of HAND remains largely unexplored. In this review, we aim to discuss and elucidate the HAND pathogenesis correlated with gut microbiome and neuroinflammation, and intend to explore the probable intervention strategies for HAND.
HIV 相关神经认知障碍 (HAND) 已成为影响 HIV 感染者 (PLWH) 生活质量的慢性神经退行性疾病。尽管 HIV 蛋白 (gp120、Tat、Rev.、Nef 和 Vpr) 引起的神经炎症与 HAND 之间存在明确关联，但 HAND 的发病机制仍有待充分阐明。越来越多的证据表明，肠道微生物组正在成为各种神经退行性疾病（例如帕金森病、阿尔茨海默病）的关键调节因子，这表明肠道微生物组与神经炎症之间的相互作用可能导致这些疾病的发生，例如，肠道菌群失调和微生物衍生代谢物可引发大脑炎症。然而，肠道微生物组在 HAND 发病机制中的潜在作用在很大程度上仍未得到探索。在这篇综述中，我们旨在讨论和阐明与肠道微生物组和神经炎症相关的 HAND 发病机制，并探讨 HAND 的可能干预策略。
