Department of Food Engineering and Technology, School of Engineering, Tezpur University, 784028, India.
Department of Physics, School of Sciences, Tezpur University, 784028, India.
Int J Biol Macromol. 2024 Feb;259(Pt 2):129305. doi: 10.1016/j.ijbiomac.2024.129305. Epub 2024 Jan 22.
In this study, we aimed to develop a blended beverage enriched with curcumin. The curcumin was incorporated within a Pickering nanoemulsion that was stabilized with nanocellulose. The nanocellulose was synthesized from coconut milk waste residue using 38 %-42 % sulfuric acid (AC) and 5 and 10 min ultrasound (UL) separately and in combination (ACU). While combined treatment showed an increase in particle size with ultrasonication time, PDI was observed to decrease. ACU with 10 min ultrasonication was further used at 0.05 %, 0.1 %, 0.2 %, and 0.3 % for stabilization of curcumin enriched Pickering nanoemulsion. The curcumin in Pickering nanoemulsion fabricated with 0.1 % of nanocellulose with an average particle size and PDI value of 259.6 nm and 0.284, respectively was found to be the most stable as compared to other Pickering nanoemulsions at different pH levels and temperatures. RP-HPLC analysis revealed that with 0.1 % of nanocellulose, the Pickering nanoemulsion was most stable at 2 pH and 63 °C temperatures. The in vitro release of curcumin from Pickering nanoemulsion added to a blended beverage in intestinal phase was 51.58 %, which was higher than the stomach phase (38.19 %). The outcomes clearly showed Pickering nanoemulsion to be a promising carrier for curcumin encapsulation in beverage.
在这项研究中,我们旨在开发一种富含姜黄素的混合饮料。姜黄素被包裹在由纳米纤维素稳定的皮克林纳米乳液中。纳米纤维素是由椰奶废渣用 38%-42%的硫酸(AC)和 5 分钟和 10 分钟的超声(UL)分别和联合(ACU)合成的。虽然联合处理随着超声时间的增加显示出粒径的增加,但 PDI 观察到减小。在 0.05%、0.1%、0.2%和 0.3%的浓度下,进一步使用处理 10 分钟的超声 ACU 来稳定富含姜黄素的皮克林纳米乳液。在不同的 pH 值和温度下,与其他皮克林纳米乳液相比,用平均粒径和 PDI 值分别为 259.6nm 和 0.284 的 0.1%纳米纤维素制备的皮克林纳米乳液中姜黄素的稳定性最高。RP-HPLC 分析表明,在 0.1%纳米纤维素的条件下,皮克林纳米乳液在 2pH 和 63°C 温度下最稳定。添加到混合饮料中的皮克林纳米乳液在肠道相中释放 51.58%的姜黄素,高于胃相中(38.19%)。结果清楚地表明,皮克林纳米乳液是一种有前途的饮料中姜黄素封装载体。