Iskandar Benni, Liu Ta-Wei, Mei Hui-Ching, Kuo I-Chih, Surboyo Meircurius Dwi Condro, Lin Hsiu-Mei, Lee Ching-Kuo
School of Pharmacy, College of Pharmacy, Taipei Medical University, Taipei 11031, Taiwan.
Department of Pharmaceutical Technology, Riau College of Pharmaceutical Sciences (STIFAR), Riau 28292, Indonesia.
J Food Drug Anal. 2024 Dec 15;32(4):428-458. doi: 10.38212/2224-6614.3526.
The rapid development of delivery systems for cosmetics has revealed two critical challenges in the field: enhancing the solubility of active ingredients and ensuring the stability of natural materials used in cosmetics. Nanoemulsion technology has emerged as an indispensable solution for addressing these challenges, not only enhancing the stability of cosmetics but also improving the solubility of pharmaceuticals and active ingredients with poor solubility. Nanoemulsion formulations have reinforced stability and amended the bioavailability of hydrophobic drugs. Moreover, nanoemulsion exhibit excellent skin penetration and long-lasting effects, making them particularly appealing to consumers, especially in the cosmetic industry. This article aims to provide an overview of herbal nanoemulsion formulations as cosmetic products, covering formulation, production, and characterization. Herbal nanoemulsions is an effective, stable, and promising option for cosmetic delivery. The nanoemulsions were characterized by their key properties, such as particle size, polydisperse index (PDI), zeta potential, viscosity, stability and others. Techniques like zeta potential measurement, transmission electron microscopy (TEM) and scanning electronmicroscopy (SEM) were used to analyze the surface morphology, whereas stability tests were employed to evaluate nanoemulsion performance. This review also delves into the high-energy and the low-energy methods of manufacturing nanoemulsions. Additionally, we also explore the selection of appropriate surfactants, co-surfactants, and ingredients for creating herbal nanoemulsions with desirable attributes and qualities. Overall, this review consolidates the current knowledge on herbal nanoemulsion formulations for cosmetic preparations, designs, shedding light on their effectiveness, characteristics, and stability. These formulations hold promise in overcoming challenges related to meeting the increasing demand for effective herbal nanoemulsion and high-quality cosmetic products.
提高活性成分的溶解度以及确保化妆品中使用的天然材料的稳定性。纳米乳液技术已成为应对这些挑战不可或缺的解决方案,不仅提高了化妆品的稳定性,还改善了药物和溶解度差的活性成分的溶解性。纳米乳液制剂增强了稳定性并改善了疏水性药物的生物利用度。此外,纳米乳液具有出色的皮肤渗透性和长效效果,使其对消费者特别有吸引力,尤其是在化妆品行业。本文旨在概述作为化妆品的草药纳米乳液制剂,涵盖制剂、生产和表征。草药纳米乳液是一种用于化妆品递送的有效、稳定且有前景的选择。纳米乳液通过其关键特性进行表征,如粒径、多分散指数(PDI)、zeta电位、粘度、稳定性等。使用zeta电位测量、透射电子显微镜(TEM)和扫描电子显微镜(SEM)等技术分析表面形态,而稳定性测试则用于评估纳米乳液性能。本综述还深入探讨了制备纳米乳液的高能和低能方法。此外,我们还探讨了选择合适的表面活性剂、助表面活性剂和成分以制备具有理想特性和品质的草药纳米乳液。总体而言,本综述巩固了当前关于用于化妆品制剂的草药纳米乳液制剂的知识,阐明了它们的有效性、特性和稳定性。这些制剂有望克服与满足对有效草药纳米乳液和高质量化妆品日益增长的需求相关的挑战。