Department of Breast and Thyroid Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
School of Public Health, Chongqing Medical University, Chongqing, China.
J Cancer Res Clin Oncol. 2024 Jan 23;150(1):28. doi: 10.1007/s00432-023-05508-1.
To explore the immune status and chronic inflammation of breast cancer patients, this study aims to analyze the diagnostic value of peripheral blood lymphocyte subsets (CD3T, CD4T, CD8T, CD3CD4CD8T, CD19B, and NK cells) and lymphocyte-to-monocyte ratio (LMR) for breast cancer. Furthermore, it seeks to examine the correlation between these subsets and LMR with clinicopathological features.
A total of 100 breast cancer patients were selected as the experimental group, while 55 patients with benign breast diseases were included in the control group. Statistical analysis, including the Wilcoxon test, Kruskal-Wallis test and the receiver operating characteristic curve, was employed to investigate the association between these serum indexes and the clinicopathological characteristics of the patients.
The levels of CD3T cells, CD4T cells, CD8T cells, CD4/CD8 ratio, NK cells, CD3CD4CD8T cells, and LMR were found to be related to the occurrence of breast cancer when analyzing data from patients with benign and malignant breast diseases. Among these biomarkers, CD3T cells, CD4T cells, CD4/CD8 ratio, CD3CD4CD8T cells, and LMR were identified as independent risk factors for breast cancer development, and the AUCs were 0.760, 0.750, 0.598, 0.697, and 0.761 (P < 0.05), respectively. Furthermore, we observed varying degrees of differences in the expression of CD3T cells, CD4T cells, CD8T cells, CD4/CD8 ratio, and LMR in lymph node metastasis, clinical staging, molecular typing, Ki-67 level (P < 0.05). However, statistical differences in histologic grade and pathology type were not found (P ≥ 0.05).
Lymphocyte subsets and LMR reflect the immune status and chronic inflammation of the body, respectively. They have certain value in the diagnosis of benign and malignant breast diseases, and correlate with lymph node metastasis, clinical staging, molecular typing and other clinicopathological features of breast cancer. Therefore, monitoring the expression of lymphocyte subsets and LMR in the body may help the auxiliary diagnosis and condition analysis of breast cancer in the clinic.
探讨乳腺癌患者的免疫状态和慢性炎症情况，旨在分析外周血淋巴细胞亚群（CD3T、CD4T、CD8T、CD3CD4CD8T、CD19B 和 NK 细胞）和淋巴细胞与单核细胞比值（LMR）对乳腺癌的诊断价值，并探讨这些亚群与 LMR 与临床病理特征的相关性。
选取 100 例乳腺癌患者作为实验组，55 例良性乳腺疾病患者作为对照组。采用 Wilcoxon 检验、Kruskal-Wallis 检验和受试者工作特征曲线分析统计分析这些血清指标与患者临床病理特征的关系。
分析良恶性乳腺疾病患者数据时发现，CD3T 细胞、CD4T 细胞、CD8T 细胞、CD4/CD8 比值、NK 细胞、CD3CD4CD8T 细胞和 LMR 水平与乳腺癌的发生有关。在这些生物标志物中，CD3T 细胞、CD4T 细胞、CD4/CD8 比值、CD3CD4CD8T 细胞和 LMR 被确定为乳腺癌发生的独立危险因素，其 AUC 分别为 0.760、0.750、0.598、0.697 和 0.761（P<0.05）。此外，我们观察到 CD3T 细胞、CD4T 细胞、CD8T 细胞、CD4/CD8 比值和 LMR 在淋巴结转移、临床分期、分子分型、Ki-67 水平上表达存在不同程度的差异（P<0.05）。然而，组织学分级和病理类型之间没有统计学差异（P≥0.05）。
淋巴细胞亚群和 LMR 分别反映了机体的免疫状态和慢性炎症情况。它们在良恶性乳腺疾病的诊断中具有一定的价值，与乳腺癌的淋巴结转移、临床分期、分子分型等临床病理特征相关。因此，监测体内淋巴细胞亚群和 LMR 的表达可能有助于乳腺癌的辅助诊断和病情分析。
