Department of Ophthalmology, Medical Faculty and University Hospital Düsseldorf - Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
Department of Ophthalmology, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Sci Rep. 2024 Jan 23;14(1):1972. doi: 10.1038/s41598-023-50985-6.
The purpose of this retrospective pseudonymised data analysis was to determine whether the patient's age has an influence on the safety, efficacy, and prediction accuracy of laser in situ keratomileusis (LASIK) treatment of myopic and hyperopic eyes. This study was performed at CARE Vision GmbH (Düsseldorf, Germany) and included two patient cohorts: an older group with patients > 55 years old and a younger group with patients 30-40 years old. Each patient had a single LASIK treatment. The safety, efficacy, and prediction accuracy of the refractive results were analysed. In total, 682 patients were analysed, with 341 patients in each patient group (one eye per patient). There were 570 myopic eyes and 112 hyperopic eyes. In myopic eyes, the efficacy was significantly influenced by the patient's age but only in myopic eyes (myopic: p ≤ 0.05; hyperopic: p = 0.085), while safety was not significantly influenced by the patient's age in hyperopic or myopic eyes (p = 0.204). We found that LASIK treatment at an older age (> 55 years) resulted in almost the same safety outcomes as a LASIK treatment at a younger age (30-40 years) but with a lower efficacy; the efficacy correlated with the patient's age. If the patient was hyperopic, their age did not influence safety or efficacy.
本回顾性去识别数据分析的目的是确定患者年龄是否会对近视和远视激光原位角膜磨镶术（LASIK）治疗的安全性、疗效和预测准确性产生影响。该研究在 CARE Vision GmbH（德国杜塞尔多夫）进行，包括两个患者队列：年龄较大组（患者年龄>55 岁）和年龄较小组（患者年龄 30-40 岁）。每位患者均接受单次 LASIK 治疗。分析了屈光结果的安全性、疗效和预测准确性。共分析了 682 名患者，每组患者 341 名（每位患者一只眼）。共有 570 只近视眼和 112 只远视眼。在近视眼中，疗效明显受患者年龄影响，但仅在近视眼中（近视：p≤0.05；远视：p=0.085），而在近视或远视眼中，安全性不受患者年龄影响（p=0.204）。我们发现，年龄较大（>55 岁）的 LASIK 治疗与年龄较小（30-40 岁）的 LASIK 治疗具有相同的安全性，但疗效较低；疗效与患者年龄相关。如果患者为远视眼，则其年龄不会影响安全性或疗效。
