Isoda Atsushi, Tahara Kenichi, Ide Munenori
Department of Hematology, Iryohojin Hoshiiin, Maebashi, JPN.
Department of Hematology, Maebashi Red Cross Hospital, Maebashi, JPN.
Cureus. 2023 Dec 23;15(12):e51010. doi: 10.7759/cureus.51010. eCollection 2023 Dec.
Kikuchi-Fujimoto disease (KFD) is a rare and self-limiting disorder that predominantly affects young individuals of Asian descent. This case report describes familial KFD in partially human leukocyte antigen (HLA)-matched siblings. An adolescent male presented with cervical lymphadenopathy and elevated lactate dehydrogenase (LDH) levels, diagnosed by biopsy as KFD; approximately one year later, his sister presented with similar symptoms. Both siblings were found to carry the HLA-DPB1*0202 allele, which is commonly associated with KFD. These cases highlight a genetic component in KFD and encourage further genetic research to delineate the pathogenesis of the disease.
菊池-藤本病（KFD）是一种罕见的自限性疾病，主要影响亚洲血统的年轻人。本病例报告描述了部分人类白细胞抗原（HLA）匹配的兄弟姐妹中的家族性KFD。一名青少年男性出现颈部淋巴结病和乳酸脱氢酶（LDH）水平升高，经活检诊断为KFD；大约一年后，他的妹妹出现了类似症状。发现这对兄弟姐妹都携带HLA-DPB1*0202等位基因，该等位基因通常与KFD相关。这些病例突出了KFD中的遗传成分，并鼓励进一步开展基因研究以阐明该疾病的发病机制。
