Singh Alok K, Vaithiyam Venkatesh, Sonika Ujjwal, Goyal Surbhi
Department of Gastroenterology, GB Pant Hospital (GIPMER), New Delhi, India.
Department of Pathology, GB Pant Hospital (GIPMER), New Delhi, India.
J Clin Exp Hepatol. 2024 May-Jun;14(3):101339. doi: 10.1016/j.jceh.2023.101339. Epub 2023 Dec 21.
Systemic lupus erythematosus (SLE) is a common multisystem disease characterised by a wide variety of presentation patterns and complex manifestations. As a lymphoid organ, the liver plays an important role in the immune response and is a target of autoimmune responses. SLE can affect the liver in approximately 25-60 % of patients during their disease course. Liver dysfunction and SLE can present with complicated differential diagnoses. Liver dysfunction in SLE is usually mild and rarely leads to advanced liver diseases such as cirrhosis and liver failure. Liver dysfunction in SLE is usually caused by non-SLE-related causes such as drug toxicity, fatty liver, alcoholism, and associated autoimmune hepatitis. However, primary liver involvement in SLE is also well-recognised. Patients with SLE who present with acute liver failure are rare. We report a rare case of SLE-associated acute severe liver injury along with a literature review.
系统性红斑狼疮（SLE）是一种常见的多系统疾病，具有多种表现形式和复杂的临床表现。作为一个淋巴器官，肝脏在免疫反应中起重要作用，并且是自身免疫反应的靶器官。在SLE患者的病程中，约25% - 60%会累及肝脏。肝功能障碍与SLE可能存在复杂的鉴别诊断。SLE中的肝功能障碍通常较轻，很少导致肝硬化和肝衰竭等晚期肝病。SLE中的肝功能障碍通常由药物毒性、脂肪肝、酒精中毒及相关自身免疫性肝炎等非SLE相关原因引起。然而，SLE原发性肝脏受累也已得到充分认识。SLE患者出现急性肝衰竭的情况较为罕见。我们报告一例罕见的SLE相关急性严重肝损伤病例并进行文献复习。
