Tekie Yohanes, Nigatu Yonas Addisu, Mekonnen Wudie, Berhe Yophtahe Woldegerima
Department of Anesthesia, Aksum University, Aksum, Ethiopia.
Department of Anesthesia, University of Gondar, Gondar, Ethiopia.
Front Oncol. 2024 Jan 9;13:1248921. doi: 10.3389/fonc.2023.1248921. eCollection 2023.
Breakthrough cancer pain (BTCP) is a transient exacerbation of pain that affects the length of hospitalization and quality of life of patients. The objective of this study was to determine the prevalence and factors associated with BTCP among cancer patients at oncology units in Northern Ethiopia in 2022.
A multi-center cross-sectional study was conducted from April to June 2022. After obtaining ethical approval, data were collected prospectively from 424 adult cancer patients admitted to oncology units. Breakthrough cancer pain was assessed by the numeric rating scale. Descriptive and binary logistic regression analyses were performed to determine the factors associated with BTCP. The strength of association was described in adjusted odds ratio (AOR) with 95% confidence intervals and variables with a P-value < 0.05 were considered to have a statistically significant association with BTCP.
The prevalence of BTCP among cancer patients was 41.5%. The factors that were found to be associated with BTCP were colorectal cancer (AOR: 7.7, 95% CI: 1.8, 32.3), lung cancer (AOR: 6.9, 95% CI: 1.9, 26.0), metastasis (AOR: 9.3, 95% CI: 3.0, 29.1), mild background pain (AOR: 7.5, 95% CI: 2.5, 22.6), moderate background pain (AOR: 7.0, 95% CI: 2.2, 23.1), severe background pain (AOR: 7.1, 95% CI: 2.2, 22.8), no analgesics taken for background pain (AOR: 5.1, 95% CI: 2.8, 9.3) and uncontrolled background pain (AOR: 3.3, 95% CI: 1.8, 6.1).
The prevalence of BTCP was high. Colorectal cancer, lung cancer, the presence of metastasis, the presence of background pain, not taking analgesics for background pain, and uncontrolled background pain were significantly associated with BTCP.
癌痛突发（BTCP）是一种疼痛的短暂加剧，会影响患者的住院时长和生活质量。本研究的目的是确定2022年埃塞俄比亚北部肿瘤科室癌症患者中BTCP的患病率及其相关因素。
2022年4月至6月进行了一项多中心横断面研究。获得伦理批准后，前瞻性收集了424名入住肿瘤科室的成年癌症患者的数据。采用数字评分量表评估癌痛突发情况。进行描述性和二元逻辑回归分析以确定与BTCP相关的因素。关联强度用调整优势比（AOR）及95%置信区间描述，P值<0.05的变量被认为与BTCP有统计学显著关联。
癌症患者中BTCP的患病率为41.5%。发现与BTCP相关的因素有结直肠癌（AOR：7.7，95%置信区间：1.8，32.3）、肺癌（AOR：6.9，95%置信区间：1.9，26.0）、转移（AOR：9.3，95%置信区间：3.0，29.1）、轻度基础疼痛（AOR：7.5，95%置信区间：2.5，22.6）、中度基础疼痛（AOR：7.0，95%置信区间：2.2，23.1）、重度基础疼痛（AOR：7.1，95%置信区间：2.2，22.8）、未服用基础疼痛镇痛药（AOR：5.1，95%置信区间：2.8，9.3）以及基础疼痛未得到控制（AOR：3.3，95%置信区间：1.8，6.1）。
BTCP的患病率较高。结直肠癌、肺癌、转移的存在、基础疼痛的存在、未服用基础疼痛镇痛药以及基础疼痛未得到控制与BTCP显著相关。
