Department of Clinical Laboratory, Affiliated Hongqi Hospital, Mudanjiang Medical University, Aimin District, Mudanjiang, 157011, China.
Department of Laboratory & Diagnosis, Changhai Hospital, Naval Medical University, Shanghai, 200433, China.
Nanomedicine (Lond). 2024 Mar;19(7):561-579. doi: 10.2217/nnm-2023-0332. Epub 2024 Jan 24.
To investigate the mechanism of doxorubicin (DOX)-induced immunogenic cell death (ICD) and to improve immunotherapy efficacy. In this study, hybrid vesicles containing DOX (HV-DOX) were prepared by thin-film hydration with extrusion, and the formulated nanoparticles were characterized physically. Furthermore, experiments and animal models were used to investigate the efficacy and new mechanisms of chemotherapy combined with immunotherapy. DOX improved tumor immunogenicity by alkalinizing lysosomes, inhibiting tumor cell autophagy and inducing ICD. HVs could activate dendritic cell maturation, synergistically enhancing chemotherapeutic immunity. The mechanism of DOX-induced ICD was explored, and antitumor immunity was synergistically activated by HV-DOX to improve chemotherapeutic drug loading and provide relevant antigenic information.
为了研究阿霉素（DOX）诱导免疫原性细胞死亡（ICD）的机制并提高免疫治疗的疗效。在这项研究中，通过薄膜水化和挤压制备了含有 DOX 的混合囊泡（HV-DOX），并对所构建的纳米粒进行了物理特性表征。此外，还通过实验和动物模型研究了化疗联合免疫治疗的疗效和新机制。DOX 通过碱化溶酶体、抑制肿瘤细胞自噬和诱导 ICD 来提高肿瘤免疫原性。HV 可激活树突状细胞成熟，协同增强化疗免疫。本研究探讨了 DOX 诱导 ICD 的机制，并通过 HV-DOX 协同激活抗肿瘤免疫，提高化疗药物载药量并提供相关的抗原信息。
Nanomedicine (Lond). 2024-3
World J Gastrointest Oncol. 2025-4-15
Zotero 插件