Loughnan B L, Sebel P S, Thomas D, Rutherfoord C F, Rogers H
Anaesthesia. 1987 Feb;42(2):195-8. doi: 10.1111/j.1365-2044.1987.tb02999.x.
The effects of fentanyl or diazepam on somatosensory, visual and brainstem auditory evoked potentials were studied in 13 healthy patients scheduled for elective surgery. Following control recordings of evoked potentials, either diazepam 20 mg or fentanyl 200 micrograms was administered intravenously. Evoked potentials were then recorded twice in the subsequent hour. No significant changes occurred in the latency or amplitude of somatosensory, visual or brainstem auditory evoked potentials. Although dose-related changes in evoked potential latencies and amplitudes have been demonstrated with both the inhalational and intravenous anaesthetics, these changes did not occur with diazepam or fentanyl used alone. An anaesthetic technique based on these two drugs would be suitable when intra-operative evoked potential monitoring is required to assess ischaemia and preservation of evoked responses.
对13例计划接受择期手术的健康患者，研究了芬太尼或地西泮对体感诱发电位、视觉诱发电位和脑干听觉诱发电位的影响。在记录诱发电位的对照值后，静脉注射20mg地西泮或200微克芬太尼。随后在接下来的一小时内记录两次诱发电位。体感诱发电位、视觉诱发电位或脑干听觉诱发电位的潜伏期或波幅均未发生显著变化。虽然吸入麻醉药和静脉麻醉药都已证实诱发电位潜伏期和波幅有剂量相关变化，但单独使用地西泮或芬太尼时并未出现这些变化。当需要术中进行诱发电位监测以评估缺血情况和保留诱发电反应时，基于这两种药物的麻醉技术将是合适的。
