Rathi Karishma, Verma Aanya, Pingat Priyanka
Assistant Professor of the Department of Pharmacy Practice at Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune.
Pharm D Intern, Department of Pharmacy Practice at Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research Pimpri, Pune.
Clin Med Insights Case Rep. 2024 Jan 23;17:11795476241226577. doi: 10.1177/11795476241226577. eCollection 2024.
Hirschsprung's disease is a congenital disorder characterized by the absence of nerve cells in the colon muscles, leading to difficulties in evacuating stool. This case report describes a newborn patient presenting with typical symptoms of the disease, including abdominal distension, constipation, diarrhea, and fever. The patient's initial laboratory investigations revealed anemia (Hb: 9.80 g/dL), low RBC count (3.50 million/cu mm), elevated RDW (16.70%), increased WBC count (11 000/cu mm), and raised platelet levels (891 000/µL) along with an elevated CRP (3.22). The baby received a comprehensive treatment regimen, including blood transfusion, Syp. MVBC, Enterogermina, Inj. Pan, Inj. Metro, Inj. Piptaz, Inj. Vancomycin, Calcium gluconate, and Inj. Aminoven. Following this treatment and necessary surgical intervention, the patient demonstrated significant improvement in frequent bowel movements and alleviation of other symptoms. This case highlights the importance of prompt diagnosis and multidisciplinary management for favorable outcomes in infants with Hirschsprung's disease.
先天性巨结肠是一种先天性疾病，其特征是结肠肌肉中缺乏神经细胞，导致排便困难。本病例报告描述了一名出现该疾病典型症状的新生儿患者，这些症状包括腹胀、便秘、腹泻和发热。患者最初的实验室检查结果显示贫血（血红蛋白：9.80 g/dL）、红细胞计数低（350万/立方毫米）、红细胞分布宽度升高（16.70%）、白细胞计数增加（11000/立方毫米）、血小板水平升高（891000/微升）以及C反应蛋白升高（3.22）。该婴儿接受了综合治疗方案，包括输血、复方胃蛋白酶合剂、亿活、泮托拉唑注射液、甲硝唑注射液、哌拉西林他唑巴坦注射液、万古霉素注射液、葡萄糖酸钙和复方氨基酸注射液。经过这种治疗和必要的手术干预后，患者在频繁排便方面有了显著改善，其他症状也有所缓解。本病例强调了对先天性巨结肠婴儿进行及时诊断和多学科管理以取得良好预后的重要性。
