澳大利亚白人群体中转铁蛋白和触珠蛋白亚型的等电聚焦研究。

Isoelectric focusing studies of transferrin and haptoglobin subtypes in an Australian white population.

作者信息

Lai L Y, Constans J, Archer G T

出版信息

Ann Hum Biol. 1986 Nov-Dec;13(6):555-61. doi: 10.1080/03014468600008731.

Abstract

This investigation presents the results of Hp and Tf subtyping of sera from 307 Australian whites by means of isoelectric focusing. Five Hp alleles were detected, these being Hp1F = 0.168, Hp1S = 0.235, Hp2FF = 0.003, Hp2FS = 0.561 and Hp2SS = 0.033. In the Tf system six alleles were found, TfC1 = 0.761, TfC2 = 0.176, TfC3 = 0.054, TfC6 = 0.002, TfB = 0.006 and TfD = 0.002. The usefulness of IEF together with modifications was highlighted for differentiating Tf and Hp subtypes; in particular, the absence of Hp2FF and Hp2SS in some earlier studies could be related to the technique used. The implication of the simultaneous presence of B and D transferrin variants in Caucasian populations is discussed.

摘要

本研究通过等电聚焦法呈现了307名澳大利亚白人血清中Hp和Tf亚型的检测结果。检测到5个Hp等位基因，分别为Hp1F = 0.168、Hp1S = 0.235、Hp2FF = 0.003、Hp2FS = 0.561和Hp2SS = 0.033。在Tf系统中发现了6个等位基因，TfC1 = 0.761、TfC2 = 0.176、TfC3 = 0.054、TfC6 = 0.002、TfB = 0.006和TfD = 0.002。强调了等电聚焦法及其改进方法在区分Tf和Hp亚型方面的实用性；特别是，一些早期研究中未出现Hp2FF和Hp2SS可能与所使用的技术有关。讨论了白种人群中同时存在B和D转铁蛋白变体的意义。