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甲状腺危象和糖尿病酮症酸中毒背景下急性神经功能缺损和低血糖一例:一种新的临床情况

A Case of Acute Neurologic Deficit and Hypoglycemia in the Setting of Thyroid Storm and Diabetic Ketoacidosis: A New Clinical Scenario.

作者信息

Aleksashina Alena, Rachina Svetlana, Kiyakbaev Gayrat, Hewathanthirige Girindu, Cherdantseva Yulia

机构信息

City Clinical Hospital Named after S.S. Yudin, Moscow, Russian Federation.

I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.

出版信息

Korean J Fam Med. 2024 Jan;45(1):51-55. doi: 10.4082/kjfm.23.0230. Epub 2024 Jan 20.

Abstract

The simultaneous development of diabetic ketoacidosis (DKA) and thyroid storm (TS) is a rare but potentially lifethreatening condition that requires immediate and targeted treatment. However, their combined diagnosis poses a serious challenge because of the similarities between their clinical manifestations. To date, only a few dozen cases have been described; most of which have been linked to the progression of thyrotoxicosis or uncontrolled hyperglycemia as contributing factors. We present the case of a 37-year-old woman with type 1 diabetes mellitus and Graves' disease who presented with both TS and DKA. She was initially admitted to the emergency department as a suspected case of stroke. Severe hypoglycemia significantly lowered her alertness to TS and probably provoked a sharp hyperthyroid decompensation, thereby leading to subsequent DKA development.

摘要

糖尿病酮症酸中毒(DKA)和甲状腺危象(TS)同时发生是一种罕见但可能危及生命的情况,需要立即进行针对性治疗。然而,由于它们临床表现相似,联合诊断面临严峻挑战。迄今为止,仅描述了几十例病例;其中大多数与甲状腺毒症进展或血糖控制不佳作为促成因素有关。我们报告一例患有1型糖尿病和格雷夫斯病的37岁女性,同时出现了TS和DKA。她最初因疑似中风被收入急诊科。严重低血糖显著降低了她对TS的警觉性,并可能引发甲状腺功能亢进急剧失代偿,从而导致随后DKA的发生。

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