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[一名既往健康男性出现甲状腺危象和糖尿病酮症酸中毒(DKA)——一项重大的鉴别诊断挑战]

[Thyroid storm and diabetic ketoacidosis (DKA) in a previously healthy male - a significant differential diagnostic challenge].

作者信息

Hessulf Fredrik, Håkansson Daniel, Nilsson Måns, Ribom-Bornefalk Eva

机构信息

Goteborgs universitet Avdelningen for molekylar och klinisk medicin - Institutionen för Medicin Goteborg, Sweden - Halmstad, Sweden.

Hallands sjukhus Halmstad - Operations och Intensivvårdskliniken Halmstad, Sweden Hallands sjukhus Halmstad - Operations och Intensivvårdskliniken Halmstad, Sweden.

出版信息

Lakartidningen. 2018 Aug 24;115:E9EY.

PMID:30152853
Abstract

Thyroid storm is a potentially lethal condition sometimes seen in cases of untreated thyrotoxicosis. Hypermetabolism, fever, and tachycardia are typical symptoms of the increased thyroid hormone activity. Thyroid storm is often triggered by infection, trauma or recent surgery and rarely by other causes. We present a case of thyroid storm and diabetic ketoacidosis (DKA) in a previously healthy male. After extensive lab testing, the patient was found to have both an undiagnosed type 1 diabetes and Graves disease. This combination of underlying conditions and the combined presentation of thyroid storm and DKA pose a significant differential diagnostic challenge, and this case report reminds us to think broadly when presented with an atypical case.

摘要

甲状腺危象是一种潜在致命的病症,有时见于未经治疗的甲状腺毒症病例。甲状腺激素活性增加的典型症状包括代谢亢进、发热和心动过速。甲状腺危象常由感染、创伤或近期手术引发,很少由其他原因引起。我们报告一例既往健康男性发生甲状腺危象和糖尿病酮症酸中毒(DKA)的病例。经过广泛的实验室检查,发现该患者患有未确诊的1型糖尿病和格雷夫斯病。这种基础疾病的组合以及甲状腺危象和DKA的合并表现带来了重大的鉴别诊断挑战,本病例报告提醒我们,遇到非典型病例时要进行全面思考。

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引用本文的文献

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Thyroid diseases - ally or enemy of type 1 diabetes in children and adolescents?甲状腺疾病——儿童和青少年 1 型糖尿病的盟友还是敌人?
Pediatr Endocrinol Diabetes Metab. 2021;27(2):117-122. doi: 10.5114/pedm.2020.101809.
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Concurrent presentation of thyroid storm and diabetic ketoacidosis: a systematic review of previously reported cases.甲状腺危象与糖尿病酮症酸中毒同时发生:既往报道病例的系统回顾。
BMC Endocr Disord. 2019 May 17;19(1):49. doi: 10.1186/s12902-019-0374-3.