Tranel D, Biller J, Damasio H, Adams H P, Cornell S H
Arch Neurol. 1987 Mar;44(3):304-8. doi: 10.1001/archneur.1987.00520150050021.
Three patients acutely developed global aphasia, but did not manifest the typical accompanying right hemiparesis. Computed tomography and magnetic resonance imaging studies demonstrated that the patients had two discrete left hemisphere lesions, one in the anterior language cortices or language-related subcortical areas, and one in the posterior language cortices. Cerebral angiography showed that two patients had complete occlusion of the left internal carotid artery, and the third had an intraluminal "clot" in the supraclinoid portion of the left internal carotid, findings suggestive of an embolic etiology. Our cases indicate that global aphasia without hemiparesis predicts two discrete lesions and a particularly good recovery of speech and language.
三名患者急性出现完全性失语，但未表现出典型的伴随右侧偏瘫。计算机断层扫描和磁共振成像研究表明，这些患者在左半球有两个不连续的病灶，一个在前语言皮层或与语言相关的皮层下区域，另一个在后语言皮层。脑血管造影显示，两名患者左侧颈内动脉完全闭塞，第三名患者左侧颈内动脉床突上段腔内有“血栓”，这些发现提示为栓塞病因。我们的病例表明，无偏瘫的完全性失语预示着有两个不连续的病灶，且言语和语言功能恢复特别良好。
