音乐对暴露于丙戊酸的成年大鼠两性认知行为障碍的影响。
Effects of music on cognitive behavioral impairments in both sex of adult rats exposed prenatally to valproic acid.
机构信息
Neuroscience Research Center, Institute of Neuropharmacology, Kerman University of Medical Sciences, Kerman, Iran.
Pathology and Stem Cell Research Center Afzalipour Medical University of Medical Science, Kerman, Iran.
出版信息
Birth Defects Res. 2024 Jan;116(1):e2300. doi: 10.1002/bdr2.2300.
BACKGROUND
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairment in reciprocal social interactions, deficits in communication, and restrictive and repetitive behaviors and interests. In previous studies, music has been identified as an intervention therapy for children with ASD.
OBJECTIVES
The present study evaluated the effects of music on cognitive behavioral impairments in both sexes of adult rats exposed prenatally to Valproic acid.
METHODS
For induction of autism, pregnant female rats were pretreated with either saline or VPA (600 mg/kg.i.p.) at gestational day (GD) 12.5. Male and female offspring were divided into Saline.Non-Music, VPA.Non-Music, Saline.Music, and VPA.Music groups. The adult rats in the music groups were exposed to Mozart's piano sonata K.448 for 30 days (4 h/day), from postnatal day (PND) 60 to 90. Social interaction and Morris water maze (MWM) tasks were tested at PND 90.
RESULTS
Our results revealed that prenatal exposure to VPA decreased sociability and social memory performance in both sexes of adult rats. Moreover, prenatal exposure to VPA created learning and memory impairments in both sexes of adult rats in the MWM task. Music intervention improved sociability in both sexes of VPA-exposed rats and social memory in both sexes of VPA-exposed rats, especially in females. Furthermore, our results revealed that music ameliorated learning impairments in VPA-exposed female rats in the MWM task. In addition, music improved spatial memory impairments in VPA-exposed rats of both sexes, especially in females, which needs more investigation in molecular and histological fields in future studies.
CONCLUSION
Music intervention improved sociability and social memory in adult VPA-exposed rats, especially in female animals. Furthermore, music improved memory impairments in VPA-exposed rats of both sexes. It seems that music had a better influence on female rats. However, future studies need more investigations in molecular and histological fields.
背景
自闭症谱系障碍（ASD）是一种神经发育障碍，其特征是在互惠社会互动、沟通障碍、以及限制和重复的行为和兴趣方面存在缺陷。在之前的研究中，音乐已被确定为 ASD 儿童的一种干预治疗方法。
目的
本研究评估了音乐对产前暴露于丙戊酸的成年雄性和雌性大鼠认知行为损伤的影响。
方法
为了诱导自闭症，在妊娠第 12.5 天，用生理盐水或 VPA（600mg/kg，ip）预处理雌性大鼠。雄性和雌性后代被分为生理盐水非音乐组、VPA 非音乐组、生理盐水音乐组和 VPA 音乐组。音乐组的成年大鼠在出生后第 60 至 90 天（PND60-PND90）期间接受莫扎特钢琴奏鸣曲 K.448 暴露 30 天（每天 4 小时）。在 PND90 时进行社会互动和 Morris 水迷宫（MWM）任务测试。
结果
我们的结果表明，产前暴露于 VPA 降低了成年雄性和雌性大鼠的社交能力和社会记忆表现。此外，产前暴露于 VPA 导致成年雄性和雌性大鼠在 MWM 任务中出现学习和记忆损伤。音乐干预改善了 VPA 暴露大鼠的社交能力和 VPA 暴露大鼠的社会记忆，特别是雌性大鼠。此外，我们的结果表明，音乐改善了 VPA 暴露雌性大鼠在 MWM 任务中的学习损伤。此外，音乐改善了 VPA 暴露大鼠的空间记忆损伤，特别是雌性大鼠，这需要在未来的研究中在分子和组织学领域进行更多的研究。
结论
音乐干预改善了成年 VPA 暴露大鼠的社交能力和社会记忆，特别是雌性动物。此外，音乐改善了 VPA 暴露大鼠的记忆损伤。音乐对雌性大鼠的影响似乎更好。然而，未来的研究需要在分子和组织学领域进行更多的研究。
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