甲状腺素对骨骼肌中钙依赖性蛋白质周转的调节。
Regulation of Ca2+-dependent protein turnover in skeletal muscle by thyroxine.
作者信息
Zeman R J, Bernstein P L, Ludemann R, Etlinger J D
出版信息
Biochem J. 1986 Nov 15;240(1):269-72. doi: 10.1042/bj2400269.
Abstract
Dantrolene, an agent that inhibits Ca2+ mobilization, improved protein balance in skeletal muscle, as thyroid status was increased, by altering rates of protein synthesis and degradation. Thyroxine (T4) caused increases in protein degradation that were blocked by leupeptin, a proteinase inhibitor previously shown to inhibit Ca2+-dependent non-lysosomal proteolysis in these muscles. In addition, T4 abolished sensitivity to the lysosomotropic agent methylamine and the autophagy inhibitor 3-methyladenine, suggesting that T4 inhibits autophagic/lysosomal proteolysis.
摘要
丹曲林是一种抑制钙离子动员的药物，随着甲状腺功能增强，它通过改变蛋白质合成和降解速率来改善骨骼肌中的蛋白质平衡。甲状腺素（T4）导致蛋白质降解增加，而这种增加被亮抑蛋白酶肽所阻断，亮抑蛋白酶肽是一种蛋白酶抑制剂，先前已证明它能抑制这些肌肉中依赖钙离子的非溶酶体蛋白水解。此外，T4消除了对溶酶体促效剂甲胺和自噬抑制剂3-甲基腺嘌呤的敏感性，这表明T4抑制自噬/溶酶体蛋白水解。
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