Institute of Laboratory Medicine, Cantonal Hospital Aarau, Aarau, Switzerland.
Graduate School for Cellular & Biomedical Sciences, University of Bern, Bern, Switzerland.
Br J Haematol. 2024 May;204(5):2066-2070. doi: 10.1111/bjh.19309. Epub 2024 Jan 26.
We assessed the diagnostic potential of erythroferrone as a biomarker for iron homeostasis comparing iron deficiency cases with anaemia of inflammation and controls. The dysregulation of the hepcidin axis was observed by Latour et al. in a mouse model of malarial anaemia induced by prolonged Plasmodium infection leading to increased erythroferrone concentrations. In line with that, we found significantly higher erythroferrone levels in cases with malaria and anaemia in an African population, compared to asymptomatic controls. Therefore, our findings extend the previous ones of the mouse model, suggesting also a dysregulation of the hepcidin axis in humans, which should be further corroborated in prospective studies and may lay the basis for the development of improved treatment strategies according to ERFE concentrations in such patients.
我们评估了红细胞生成素作为铁稳态生物标志物的诊断潜力，将缺铁病例与炎症性贫血和对照组进行了比较。Latour 等人在由长期疟原虫感染引起的疟原虫性贫血小鼠模型中观察到铁调素轴的失调，导致红细胞生成素浓度增加。与此一致，我们发现在非洲人群中，疟疾和贫血病例的红细胞生成素水平明显高于无症状对照组。因此，我们的研究结果扩展了之前在小鼠模型中的发现，表明人类铁调素轴也存在失调，这需要在前瞻性研究中进一步证实，并可能为根据此类患者的 ERFE 浓度制定改进的治疗策略奠定基础。
