Department of Cardiac Surgery, University of Clinical Center of Serbia, Belgrade, Serbia.
University Hospital Medical Center Bežanijska Kosa, Belgrade, Serbia.
Gen Thorac Cardiovasc Surg. 2024 Aug;72(8):512-518. doi: 10.1007/s11748-023-02007-5. Epub 2024 Jan 27.
Degenerative aortic stenosis and coronary artery disease are considered to be the most prevalent cardiovascular diseases in industrialized countries. This study aims to determine the change over time in von Willebrand factor antigen, von Willebrand factor activity, and factor VIII and where there is a correlation with total post-operative drainage.
The single-center retrospective study included 203 consecutive patients (64.5% male), undergoing coronary artery bypass surgery between March 1, 2019 and June 30, 2020 at the University Clinical Center of Serbia in the Clinic for Cardiac Surgery in Belgrade, Serbia. All patients 18 years or older who presented with isolated, hemodynamically significant aortic stenosis were included. The control group consisted of patients who presented with only coronary artery disease.
Between patients with only coronary artery disease and patients with coronary artery diseases and aortic stenosis, there was a statistically significant difference between pre-op and 1-month post-op fibrinogen, factor VIII, von Willebrand factor antigen, and von Willebrand factor (p < 0.001), post-op drainage, with overall lower drainage in coronary artery disease patients, and consistent increase in von Willebrand factor antigen, von Willebrand factor activity, and Factor VIII post-operatively in patients with coronary artery diseases and aortic stenosis.
This study has shown that there is a correlation between von Willebrand factor antigen, von Willebrand factor activity and total drainage to the level of statistical significance in aortic stenosis patients and in the overall study population.
退行性主动脉瓣狭窄和冠状动脉疾病被认为是工业化国家最常见的心血管疾病。本研究旨在确定血管性血友病因子抗原、血管性血友病因子活性和因子 VIII 的时间变化，并确定它们与总术后引流之间的相关性。
这项单中心回顾性研究纳入了 203 例连续患者（64.5%为男性），于 2019 年 3 月 1 日至 2020 年 6 月 30 日在塞尔维亚贝尔格莱德心脏外科临床中心的塞尔维亚大学临床中心接受冠状动脉旁路手术。所有年龄在 18 岁或以上且存在孤立性、血流动力学显著主动脉瓣狭窄的患者均被纳入。对照组由仅患有冠状动脉疾病的患者组成。
在仅患有冠状动脉疾病的患者和同时患有冠状动脉疾病和主动脉瓣狭窄的患者之间，术前和术后 1 个月的纤维蛋白原、因子 VIII、血管性血友病因子抗原和血管性血友病因子存在统计学显著差异（p<0.001），术后引流方面，仅患有冠状动脉疾病的患者的总体引流较低，而同时患有冠状动脉疾病和主动脉瓣狭窄的患者术后血管性血友病因子抗原、血管性血友病因子活性和因子 VIII 持续增加。
本研究表明，在主动脉瓣狭窄患者和总体研究人群中，血管性血友病因子抗原、血管性血友病因子活性和总引流之间存在相关性，达到统计学意义水平。
