Laboratory of Microvascular Medicine, Medical Research Center, Shandong Provincial Qianfoshan Hospital, The First Affiliated Hospital of Shandong First Medical University, 16766 Jingshi Road, Jinan, 250014, Shandong, China.
Graduate School, Shandong First Medical University & Shandong Academy of Medical Sciences, Jinan, China.
BMC Cardiovasc Disord. 2020 Feb 10;20(1):72. doi: 10.1186/s12872-020-01375-7.
Prediction of major adverse cardiovascular events (MACEs) may offer great benefits for patients with coronary artery disease (CAD). Von Willebrand factor (vWF) is stored in endothelial cells and released into blood plasma upon vascular dysfunction. This meta-analysis was performed to evaluate the prognostic value of plasma vWF levels in CAD patients with MACEs.
A total of 15 studies were included in this meta-analysis through the search in PubMed, Embase and CNKI. Data were collected from 960 patients who had MACEs after CAD and 3224 controls nested without the adverse events. The standard mean difference (SMD) and 95% confidence intervals (95% CI) were calculated using random-effects model.
The plasma vWF levels examined at 24 h and 48 h after admission were significantly higher in CAD patients with MACEs than those without. The pooled SMD among the MACEs group and the non-MACEs group was 0.55 (95% CI = 0.30-0.80, P < 0.0001) and 0.70 (95% CI = 0.27-1.13, P = 0.001), respectively. However, no significant difference was found in plasma vWF levels on admission between the two groups.
Plasma vWF level in CAD patients examined at 24 h and 48 h after admission might be an independent prognostic factor for MACE.
预测主要不良心血管事件（MACE）可能会为冠心病（CAD）患者带来巨大益处。血管性血友病因子（vWF）储存于血管内皮细胞中，血管功能障碍时释放入血。本荟萃分析旨在评估 CAD 患者 MACE 时血浆 vWF 水平的预后价值。
通过在 PubMed、Embase 和中国知网（CNKI）中检索，共纳入 15 项研究。共纳入 960 例发生 CAD 后发生 MACE 的患者和 3224 例无不良事件的对照患者。使用随机效应模型计算标准均数差（SMD）和 95%置信区间（95%CI）。
入院后 24 h 和 48 h 检测的 CAD 患者血浆 vWF 水平明显高于无 MACE 患者。MACE 组和非 MACE 组的血浆 vWF 水平的合并 SMD 分别为 0.55（95%CI=0.30-0.80，P<0.0001）和 0.70（95%CI=0.27-1.13，P=0.001）。然而，两组入院时血浆 vWF 水平无显著差异。
入院后 24 h 和 48 h 检测的 CAD 患者血浆 vWF 水平可能是 MACE 的独立预后因素。
