Erciyes University Medical School, Department of Endocrinology, Kayseri, Turkey.
Erciyes University Medical School, Department of Endocrinology, Kayseri, Turkey.
Growth Horm IGF Res. 2024 Feb;74:101571. doi: 10.1016/j.ghir.2024.101571. Epub 2024 Jan 23.
Growth hormone (GH) has been recognized to play a regulatory role in female reproduction. It has been reported that infertile GH deficient patients regained fertility after GH replacement. The frequency of GH deficiency is not established in patients diagnosed with unexplained infertility. Here, we aim to present the prevalence of GH deficieny in this patient group.
We included patients diagnosed with unexplained infertility throughout 18 months. Insulin tolerance test (ITT) and glucagon stimulation tests (GST) were performed and insufficient response to both tests was required for the diagnosis of GH deficiency.
Twenty-five patients were included in the study, the mean age was 27.4 ± 4.5 years and the median duration of infertility was 60 months (min:14, max:120). Two patients were GH deficient according to GST and 14 to ITT. Two patients (8%) showed lack of response on both tests and were diagnosed with GH deficiency.
The rate of GH deficiency among women with unexplained infertility was 8% in this preliminary study. There is need for further studies with larger patient groups to verify the results.
生长激素（GH）已被认为在女性生殖中起调节作用。有报道称，缺乏 GH 的不孕患者在接受 GH 替代治疗后恢复了生育能力。在被诊断为不明原因不孕的患者中，GH 缺乏的频率尚未确定。在这里，我们旨在报告该患者群体中 GH 缺乏的患病率。
我们纳入了 18 个月内被诊断为不明原因不孕的患者。进行了胰岛素耐量试验（ITT）和胰高血糖素刺激试验（GST），并且需要对这两种试验均无反应才能诊断为 GH 缺乏。
本研究共纳入 25 例患者，平均年龄为 27.4 ± 4.5 岁，不孕持续时间中位数为 60 个月（最小：14，最大：120）。根据 GST，有 2 名患者 GH 缺乏，根据 ITT，有 14 名患者 GH 缺乏。有 2 名患者（8%）两种检测均无反应，被诊断为 GH 缺乏。
在这项初步研究中，不明原因不孕女性的 GH 缺乏率为 8%。需要进一步的研究来验证更大患者群体的结果。
