Rotheneder M, Kostner G M
Biol Chem Hoppe Seyler. 1986 Dec;367(12):1219-22. doi: 10.1515/bchm3.1986.367.2.1219.
Mouse peritoneal macrophages were incubated with abnormal lipoproteins (LP-X, HDL-E, VLDL-p, IDl-p and LDL-p) from a patient with secondary deficiency in phosphatidylcholine-sterol acyltransferase, or with phosphatidylcholine/cholesterol liposomes, and the stimulation of cholesteryl ester formation was studied. Acetylated low density lipoproteins served as a control. It was found that macrophages incubated with LP-X, the other pathological lipoproteins or with liposomes did not show an enhanced cholesterol esterification. Also HDL-E had no effect despite of its high apoE content and the fact that apoE has been postulated to be the agonist in beta-VLDL binding to macrophages.
将患有磷脂酰胆碱-胆固醇酰基转移酶继发性缺乏症患者的异常脂蛋白（LP-X、HDL-E、VLDL-p、IDl-p和LDL-p）或磷脂酰胆碱/胆固醇脂质体与小鼠腹膜巨噬细胞一起孵育，研究胆固醇酯形成的刺激情况。乙酰化低密度脂蛋白用作对照。发现与LP-X、其他病理性脂蛋白或脂质体一起孵育的巨噬细胞未显示胆固醇酯化增强。尽管HDL-E具有高载脂蛋白E含量且据推测载脂蛋白E是β-VLDL与巨噬细胞结合的激动剂，但它也没有作用。
