Cremoni L, Buffa D, Sauco F, Bongetta R, Arosio M, d'Amico P
Boll Ist Sieroter Milan. 1986;65(5):430-5.
Anti-HBc IgM were determined in 46 patients whose serum was positive for hepatitis B surface antigen (HBsAg). All sera were tested from 1:4000 up to 1:8128000 dilution with a radioimmunometric assay. Anti-HBc IgM persisted at detectable level for up 15 months from acute infection in more than 50% of the patients. High levels of anti-HBc IgM are seen only in the acute phase but it is difficult to establish a cut-off dilution displaying diagnostic value between current and remote infection. Anti-HBc IgM are always detectable in acute hepatitis B virus (HBV) so that the absence of HBc IgM in acute hepatitis with positive HBsAg allows to discard HBV as the causative agent and to suspect a non-B hepatitis (A, delta, NANB). On the contrary the presence of anti-HBc IgM in detectable amounts in patients with acute hepatitis and negative HBsAg makes possible the diagnosis of acute B virus hepatitis.
对46例乙型肝炎表面抗原（HBsAg）血清阳性患者检测了抗-HBc IgM。所有血清均采用放射免疫分析法从1:4000至1:8128000稀释度进行检测。在超过50%的患者中，抗-HBc IgM在急性感染后长达15个月可维持在可检测水平。高浓度的抗-HBc IgM仅见于急性期，但难以确定一个能区分近期感染和既往感染的具有诊断价值的临界稀释度。急性乙型肝炎病毒（HBV）感染时抗-HBc IgM总是可检测到的，因此，HBsAg阳性的急性肝炎患者若不存在抗-HBc IgM，则可排除HBV作为病原体，而怀疑为非B型肝炎（甲型、丁型、非甲非乙型）。相反，急性肝炎且HBsAg阴性患者若存在可检测量的抗-HBc IgM，则可诊断为急性乙型病毒性肝炎。
