Department of Psychiatry, Wroclaw Medical University, Wroclaw, Poland.
Laboratory of Immunopathology, Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland.
J Psychiatr Res. 2024 Mar;171:152-160. doi: 10.1016/j.jpsychires.2024.01.036. Epub 2024 Jan 23.
The present study had the following aims: 1) to compare gut microbiota composition in patients with schizophrenia and controls and 2) to investigate the association of differentially abundant bacterial taxa with markers of inflammation, intestinal permeability, lipid metabolism, and glucose homeostasis as well as clinical manifestation. A total of 115 patients with schizophrenia during remission of positive and disorganization symptoms, and 119 controls were enrolled. Altogether, 32 peripheral blood markers were assessed. A higher abundance of Eisenbergiella, Family XIII AD3011 group, Eggerthella, Hungatella, Lactobacillus, Olsenella, Coprobacillus, Methanobrevibacter, Ligilactobacillus, Eubacterium fissicatena group, and Clostridium innocuum group in patients with schizophrenia was found. The abundance of Paraprevotella and Bacteroides was decreased in patients with schizophrenia. Differentially abundant genera were associated with altered levels of immune-inflammatory markers, zonulin, lipid profile components, and insulin resistance. Moreover, several correlations of differentially abundant genera with cognitive impairment, higher severity of negative symptoms, and worse social functioning were observed. The association of Methanobrevibacter abundance with the level of negative symptoms, cognition, and social functioning appeared to be mediated by the levels of interleukin-6 and RANTES. In turn, the association of Hungatella with the performance of attention was mediated by the levels of zonulin. The findings indicate that compositional alterations of gut microbiota observed in patients with schizophrenia correspond with clinical manifestation, intestinal permeability, subclinical inflammation, lipid profile alterations, and impaired glucose homeostasis. Subclinical inflammation and impaired gut permeability might mediate the association of gut microbiota alterations with psychopathological symptoms and cognitive impairment.
1）比较精神分裂症患者和对照组的肠道微生物群落组成，2）探讨差异丰度细菌分类群与炎症标志物、肠道通透性、脂质代谢和葡萄糖稳态以及临床症状的关联。共纳入 115 例处于阳性和瓦解症状缓解期的精神分裂症患者和 119 例对照者。共评估了 32 种外周血标志物。发现精神分裂症患者中 Eisenbergiella、Family XIII AD3011 组、Eggerthella、Hungatella、Lactobacillus、Olsenella、Coprobacillus、Methanobrevibacter、Ligilactobacillus、Eubacterium fissicatena 组和 Clostridium innocuum 组的丰度较高。精神分裂症患者中 Paraprevotella 和 Bacteroides 的丰度降低。差异丰度的属与免疫炎症标志物、紧密连接蛋白、脂质谱成分和胰岛素抵抗的改变水平相关。此外，还观察到一些差异丰度的属与认知障碍、更严重的阴性症状和较差的社会功能之间存在相关性。Methanobrevibacter 丰度与阴性症状、认知和社会功能水平的关联似乎是由白细胞介素-6 和 RANTES 水平介导的。反过来，Hungatella 与注意力表现的关联是由紧密连接蛋白的水平介导的。研究结果表明，精神分裂症患者肠道微生物群落的组成改变与临床表现、肠道通透性、亚临床炎症、脂质谱改变和葡萄糖稳态受损有关。亚临床炎症和肠道通透性受损可能介导肠道微生物群落改变与精神病理症状和认知障碍的关联。
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