Melnik B, Glück S, Jungblut R M, Goerz G
Br J Dermatol. 1987 Feb;116(2):207-12. doi: 10.1111/j.1365-2133.1987.tb05813.x.
Radiographic skeletal examinations were performed in eight adult patients who had received the aromatic retinoid etretinate for various disorders of keratinization over periods ranging from 1 to 7 years. Age- and sex-matched controls were also examined. In all patients, alterations of ossification were found to a varying degree, including calcification of the anterior spinal ligament, vertebral hyperostoses at the anterosuperior and anteroinferior margins of the vertebral bodies, unilateral bridging of vertebral bodies, hyperostoses of the calcanei at the insertion of the plantar ligament and bone accretion at the anterolateral lips of the acetabula. All the bone changes were asymptomatic. Serum calcium, inorganic phosphate, alkaline phosphatase, calcitonin and parathormone were within normal physiological ranges. In general, the bone changes observed after long-term etretinate treatment closely resembled the effects of isotretinoin on the skeleton.
对8名成年患者进行了骨骼X线检查，这些患者因各种角化异常疾病接受芳香维甲酸依曲替酯治疗达1至7年。同时检查了年龄和性别匹配的对照者。在所有患者中，均发现不同程度的骨化改变，包括前纵韧带钙化、椎体前上缘和前下缘的椎体骨质增生、椎体单侧桥接、跟骨在足底韧带附着处的骨质增生以及髋臼前外侧唇的骨质增生。所有骨改变均无症状。血清钙、无机磷、碱性磷酸酶、降钙素和甲状旁腺激素均在正常生理范围内。总体而言，长期依曲替酯治疗后观察到的骨改变与异维甲酸对骨骼的影响非常相似。
