Laparo Obeso Centre (LOC Healthcare LLP), University of Bergen, Pune, India.
Obes Surg. 2024 Mar;34(3):836-840. doi: 10.1007/s11695-024-07075-x. Epub 2024 Jan 29.
With the increase in obesity epidemic among Asians, it is necessary to evaluate the impact of obesity on this population. Low testosterone levels are known to be associated with obesity. This is the 1st study from Asia to evaluate incidence and magnitude of hypotestosteronemia in young adults with BMI more than 32.5 kg/m defined as moderate to severe obesity in Asians.
One hundred thirty-four male patients with BMI more than 32.5 kg/m, between 18 and 30 years old who visited a single bariatric facility between 2017 and 2020, were evaluated with BMI, total and free testosterone levels and clinical features of gynecomastia, hypogonadism, and thinning of pubic and armpit hair. Statistical analysis was performed using SPSS, Spearman's correlation coefficient, and ANOVA test.
60.4% of patients (84/134) had low testosterone levels (< 300 ng/dl) and 23.9% (32/134) had levels between 300 and 400 ng/dl. 89.6% patients (120/134 had gynecomastia, 60.4% (81/134) had thinning of pubic and arm pit hair, and 62.7% (84/134) had hypogonadism. Testosterone levels showed a decreasing trend with increasing BMI, but it was not statistically significant.
Obesity is one of the important etiologies of hypotestosteronemia and its manifestations in young adults. The actual incidence may be significantly higher than what is reported in the literature. High-quality research is required to address questions of diagnosis and best treatment options.
随着亚洲肥胖症的流行，有必要评估肥胖对该人群的影响。众所周知，低睾酮水平与肥胖有关。这是亚洲第 1 项评估 BMI 超过 32.5kg/m2（亚洲定义为中度至重度肥胖）的年轻成年人中低睾血症发生率和严重程度的研究。
2017 年至 2020 年间，134 名 BMI 超过 32.5kg/m2、年龄在 18 至 30 岁之间的男性患者在单一减肥机构就诊，对其进行 BMI、总睾酮和游离睾酮水平以及乳房发育、性腺功能减退和阴毛腋毛变薄等临床特征评估。使用 SPSS、斯皮尔曼相关系数和 ANOVA 检验进行统计分析。
60.4%（84/134）的患者睾酮水平较低（<300ng/dl），23.9%（32/134）的患者睾酮水平在 300-400ng/dl 之间。89.6%（120/134）的患者有乳房发育，60.4%（81/134）的患者阴毛腋毛变薄，62.7%（84/134）的患者性腺功能减退。睾酮水平随 BMI 的增加呈下降趋势，但无统计学意义。
肥胖是低睾血症的重要病因之一，也是年轻成年人低睾血症的表现之一。实际发病率可能远高于文献报道。需要高质量的研究来解决诊断和最佳治疗方案的问题。
