强化正念冥想可降低偏头痛的发作频率和负担：一项非盲单臂试验。

Intensive Mindfulness Meditation Reduces Frequency and Burden of Migraine: An Unblinded Single-Arm Trial.

作者信息

Goyal Madhav, Haythornthwaite Jennifer A, Jain Sharat, Peterlin Barbara Lee, Mehrotra Megha, Levine David, Rosenberg Jason D, Minges Mary, Seminowicz David A, Ford Daniel E

机构信息

Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, USA.

Center for Primary Care, NorthBay Healthcare, Vacaville, CA, USA.

出版信息

Mindfulness (N Y). 2023 Feb;14(2):406-417. doi: 10.1007/s12671-023-02073-z. Epub 2023 Jan 24.

DOI:10.1007/s12671-023-02073-z

PMID:38282695

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10810247/

Abstract

OBJECTIVES

Preventing migraine headaches and improving the quality of life for patients with migraine remains a challenge. We hypothesized intensive meditation training would reduce the disease burden of migraine.

METHOD

An unblinded trial was analyzed as a single cohort exposed to a silent 10-day Vipassana meditation retreat that included 100 hr of sitting meditation. Participants with chronic or episodic migraine were enrolled and followed for 1 year. The primary outcome was a change in mean monthly migraine days at 12 months from baseline. Secondary outcomes included headache frequency and intensity, acute medication use, work days missed, home meditation, sleep quality, general health, quality of life, migraine impact, positive and negative affect, perceived stress, mindfulness, and pain catastrophizing.

RESULTS

Three hundred people were screened and 58 (19%) agreed to participate and enrolled in the intensive meditation training. Forty-six participants with chronic migraine (≥ 15 headaches/month of which ≥ 8 were migraines) and 12 with episodic migraine (< 15 and ≥ 4 migraines/month) attended and 45 (78%) completed the retreat. At 12 months, the average migraine frequency was reduced by 2.7 days (from 16.6 at baseline) per 28 days (95%CI - 4.3, - 1.3) and headaches by 3.4 (20.1 at baseline) per 28 days (- 4.9, - 1.9). Fifty percent responder rate was 29% for migraine. Acute medication use dropped by an average of 2.2 days (- 3.9, - 0.5) per 28 days, and participants reported 2.3 fewer days (- 4.0, - 0.5) on which they reduced their activity due to migraines. The most striking and promising effects were in several secondary outcomes, including migraine-specific quality of life, pain catastrophizing, and perceived stress. The significant improvements observed immediately following the intervention were sustained at 12 months follow-up.

CONCLUSIONS

Training in Vipassana meditation via a 10-day retreat may reduce the frequency and burden of migraine.

PREREGISTRATION

ClinicalTrials.gov: NCT00663585.

摘要

目的

预防偏头痛并改善偏头痛患者的生活质量仍然是一项挑战。我们假设强化冥想训练会减轻偏头痛的疾病负担。

方法

一项非盲试验作为单个队列进行分析，该队列参加了为期10天的内观冥想静修，其中包括100小时的坐禅。纳入慢性或发作性偏头痛患者并随访1年。主要结局是12个月时每月偏头痛平均天数相对于基线的变化。次要结局包括头痛频率和强度、急性药物使用情况、误工天数、在家冥想情况、睡眠质量、总体健康状况、生活质量、偏头痛影响、积极和消极情绪、感知压力、正念及疼痛灾难化。

结果

筛查了300人，58人（19%）同意参加并接受强化冥想训练。46名慢性偏头痛患者（每月≥15次头痛，其中≥8次为偏头痛）和12名发作性偏头痛患者（每月<15次且≥4次偏头痛）参加，45人（78%）完成静修。12个月时，每28天平均偏头痛频率减少2.7天（从基线时的16.6天）（95%置信区间-4.3，-1.3），头痛次数每28天减少3.4次（基线时为20.1次）（-4.9，-1.9）。偏头痛的50%缓解率为29%。急性药物使用量每28天平均减少2.2天（-3.9，-0.5），参与者报告因偏头痛而减少活动的天数减少2.3天（-4.0，-0.5）。最显著且有前景的效果体现在几个次要结局上，包括偏头痛特异性生活质量、疼痛灾难化和感知压力。干预后立即观察到的显著改善在12个月随访时得以维持。