Jiao Yunke, Lei Miao, Zhu Jianwei, Chang Ronghang, Qu Xue
Key Laboratory for Ultrafine Materials of Ministry of Education, School of Material Science and Engineering, Frontiers Science Center for Materiobiology and Dynamic Chemistry, East China University of Science and Technology, Shanghai, China.
Wenzhou Institute of Shanghai University, Wenzhou, Zhejiang Province, China.
Biomater Transl. 2023 Dec 28;4(4):213-233. doi: 10.12336/biomatertransl.2023.04.003. eCollection 2023.
Recent advances in neuroelectrode interface materials and modification technologies are reviewed. Brain-computer interface is the new method of human-computer interaction, which not only can realise the exchange of information between the human brain and external devices, but also provides a brand-new means for the diagnosis and treatment of brain-related diseases. The neural electrode interface part of brain-computer interface is an important area for electrical, optical and chemical signal transmission between brain tissue system and external electronic devices, which determines the performance of brain-computer interface. In order to solve the problems of insufficient flexibility, insufficient signal recognition ability and insufficient biocompatibility of traditional rigid electrodes, researchers have carried out extensive studies on the neuroelectrode interface in terms of materials and modification techniques. This paper introduces the biological reactions that occur in neuroelectrodes after implantation into brain tissue and the decisive role of the electrode interface for electrode function. Following this, the latest research progress on neuroelectrode materials and interface materials is reviewed from the aspects of neuroelectrode materials and modification technologies, firstly taking materials as a clue, and then focusing on the preparation process of neuroelectrode coatings and the design scheme of functionalised structures.
综述了神经电极界面材料及修饰技术的最新进展。脑机接口是一种新型人机交互方式,不仅能实现人脑与外部设备间的信息交换,还为脑部相关疾病的诊断与治疗提供了全新手段。脑机接口的神经电极界面部分是脑组织系统与外部电子设备间电、光和化学信号传输的重要领域,决定着脑机接口的性能。为解决传统刚性电极柔韧性不足、信号识别能力不足及生物相容性不足等问题,研究人员在神经电极界面的材料及修饰技术方面开展了广泛研究。本文介绍了神经电极植入脑组织后发生的生物反应以及电极界面对电极功能的决定性作用。在此基础上,从神经电极材料及修饰技术方面综述了神经电极材料和界面材料的最新研究进展,首先以材料为线索,然后重点关注神经电极涂层的制备工艺及功能化结构的设计方案。