[在贝宁科托努参与一项HIV暴露前预防示范研究的男男性行为者中乙型和丙型病毒性肝炎的患病率]

[Prevalence of viral hepatitis B and C in men who have sex with men enrolled in a demonstration study of pre-exposure prophylaxis for HIV in Cotonou, Benin].

作者信息

Béhanzin Luc, Diabaté Souleymane, Guédou Fernand Aimé, Matsétsé Ella Goma, Olodo Marius, Dossouvo Alban, Aza-Gnandji Marlène, Akpaka Axel, Chagas Elyote, Gangbo Flore, Zannou Djimon Marcel, Alary Michel

机构信息

École Nationale de Formation des Techniciens Supérieurs en Santé Publique et en Surveillance Epidémiologique, Université de Parakou, Parakou, Bénin.

Organisation pour la Promotion de la Santé et le Développement Communautaire, Cotonou, Bénin.

出版信息

Pan Afr Med J. 2023 Nov 9;46:79. doi: 10.11604/pamj.2023.46.79.41013. eCollection 2023.

DOI:10.11604/pamj.2023.46.79.41013

PMID:38282778

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10819840/

Abstract

INTRODUCTION

men who have sex with men (MSM) are disproportionately affected by hepatitis B virus (HBV) and hepatitis C virus (HCV) worldwide. In Benin, there are no data on MSM. The purpose of this study was to estimate HBV and HCV prevalence and HBV-associated factors in MSM who were HIV negative.

METHODS

we conducted an analytical cross-sectional study. A two-degree random sampling was used to recruit 204 MSM. An immunochromatographic rapid test and enzyme immunoassays were used to detect HBV and HCV antigens/antibodies. Log-binomial regression was used to identify factors associated with HBV.

RESULTS

HbsAg positivity, history of hepatitis B infection and hepatitis C prevalences were 37.7%, 8.8 %, and 0.9 %, respectively. HBsAg positivity and history of hepatitis B were more prevalent in MSM aged ≥30 years compared to younger subjects: 16.7% versus 6.4% (p<0.0001) and 66.7% versus 28.8% (p<0.0001), respectively. Sexual intercourse under the effect of drug or alcohol and living in couple were also associated with HBV.

CONCLUSION

the prevalence of hepatitis C was low, but hepatitis B was common, especially among older MSM. Screening and vaccination against hepatitis B should be strengthened in this population.

摘要

引言

在全球范围内，男男性行为者（MSM）感染乙型肝炎病毒（HBV）和丙型肝炎病毒（HCV）的比例过高。在贝宁，尚无关于男男性行为者的数据。本研究的目的是估计HIV阴性的男男性行为者中HBV和HCV的流行率以及与HBV相关的因素。

方法

我们进行了一项分析性横断面研究。采用两阶段随机抽样招募了204名男男性行为者。使用免疫层析快速检测和酶免疫测定法检测HBV和HCV抗原/抗体。采用对数二项回归来确定与HBV相关的因素。

结果

HBsAg阳性率、乙型肝炎感染史和丙型肝炎流行率分别为37.7%、8.8%和0.9%。与较年轻的男男性行为者相比，≥30岁的男男性行为者中HBsAg阳性率和乙型肝炎感染史更为普遍：分别为16.7%对6.4%（p<0.0001）和66.7%对28.8%（p<0.0001）。在药物或酒精影响下进行性行为以及同居也与HBV有关。