Gao Shiyu, Li Sheng, Wu Heming, Yuan Yi, Ding Xu, Zhao Jing, Wang Ailing, Cao Xiumeng, Du Hongming
Department of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, PR China.
Jiangsu Key Laboratory of Oral Disease, Nanjing Medical University, Nanjing, Jiangsu Province, 210029, PR China.
World Allergy Organ J. 2024 Jan 5;17(2):100864. doi: 10.1016/j.waojou.2023.100864. eCollection 2024 Feb.
Allergic parotitis (AP), due to its non-specific symptoms, frequently poses a diagnostic challenge, leading to cases being overlooked or misdiagnosed by clinicians.
This study aimed to elucidate detailed clinical characteristics and common diagnostic indicators of AP.
A comprehensive review and analysis of medical records was conducted from patients diagnosed with AP, encompassing demographic, clinical, and laboratory data, at the Affiliated Stomatological Hospital of Nanjing Medical University between January 2019 and March 2022.
The study enrolled 17 patients, evidenced by an average age of 36.00 ± 12.95 years. Common presentations of AP among the patients included notable symptoms such as parotid gland swelling, associated pain, and xerostomia. Ten patients had other atopic diseases. Palpation revealed the affected parotid glands to be soft and nodular, with an elevated local skin temperature. The unstimulated whole saliva flow rate was decreased. Ultrasonography demonstrated increased volume, reduced echo heterogeneity, and lymph node enlargement in the affected parotid glands. All cases observed increased serum salivary amylase and total IgE levels. Investigation of food allergens and inhaled allergen-specific IgE showed that all patients had suspected food allergies. Food provocation tests (FPT) induced AP in 13 cases, confirming the role of food allergens.
Food allergens are involved in the etiology of AP, underscoring the importance of comprehensive clinical evaluation, including symptoms, signs, and confirmatory auxiliary tests, such as FPT, for accurate diagnosis and differentiation from other salivary gland pathologies.
过敏性腮腺炎（AP）因其症状不具特异性，常常带来诊断挑战，导致临床医生漏诊或误诊病例。
本研究旨在阐明AP的详细临床特征和常见诊断指标。
对2019年1月至2022年3月期间在南京医科大学附属口腔医院被诊断为AP的患者的病历进行了全面回顾和分析，涵盖人口统计学、临床和实验室数据。
该研究纳入了17例患者，平均年龄为36.00 ± 12.95岁。患者中AP的常见表现包括腮腺肿大、相关疼痛和口干等明显症状。10例患者患有其他特应性疾病。触诊显示患侧腮腺柔软且有结节，局部皮肤温度升高。非刺激性全唾液流速降低。超声检查显示患侧腮腺体积增大、回声不均匀性降低和淋巴结肿大。所有病例血清唾液淀粉酶和总IgE水平均升高。食物过敏原和吸入性过敏原特异性IgE检测显示所有患者均有疑似食物过敏。食物激发试验（FPT）在13例患者中诱发了AP，证实了食物过敏原的作用。
食物过敏原参与了AP的病因，强调了全面临床评估的重要性，包括症状、体征以及如FPT等确证性辅助检查，以准确诊断并与其他唾液腺疾病相鉴别。
