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treadmill 训练通过抑制 CX3CL1 预防 TBI 愈合过程中破骨细胞诱导的纤维软骨复合体吸收。

Inhibition of CX3CL1 by treadmill training prevents osteoclast-induced fibrocartilage complex resorption during TBI healing.

机构信息

Department of Sports Medicine, Southwest Hospital, Army Medical University, Chongqing, China.

Pancreatic Injury and Repair Key Laboratory of Sichuan Province, The General Hospital of Western Theater Command, Chengdu, Sichuan, China.

出版信息

Front Immunol. 2024 Jan 12;14:1295163. doi: 10.3389/fimmu.2023.1295163. eCollection 2023.

DOI:10.3389/fimmu.2023.1295163
PMID:38283363
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10811130/
Abstract

INTRODUCTION

The healing of tendon-bone injuries is very difficult, often resulting in poor biomechanical performance and unsatisfactory functional recovery. The tendon-bone insertion has a complex four distinct layers structure, and previous studies have often focused on promoting the regeneration of the fibrocartilage layer, neglecting the role of its bone end repair in tendon-bone healing. This study focuses on the role of treadmill training in promoting bone regeneration at the tendon-bone insertion and its related mechanisms.

METHODS

After establishing the tendon-bone insertion injury model, the effect of treadmill training on tendon-bone healing was verified by Micro CT and HE staining; then the effect of CX3CL1 on osteoclast differentiation was verified by TRAP staining and cell culture; and finally the functional recovery of the mice was verified by biomechanical testing and behavioral test.

RESULTS

Treadmill training suppresses the secretion of CX3CL1 and inhibits the differentiation of local osteoclasts after tendon-bone injury, ultimately reducing osteolysis and promoting tendon bone healing.

DISCUSSION

Our research has found the interaction between treadmill training and the CX3CL1-C3CR1 axis, providing a certain theoretical basis for rehabilitation training.

摘要

简介

肌腱-骨损伤的愈合非常困难，往往导致生物力学性能不佳和功能恢复不满意。肌腱-骨附着处具有复杂的四层结构，先前的研究通常侧重于促进纤维软骨层的再生，而忽略了其骨端修复在肌腱-骨愈合中的作用。本研究重点关注跑步机训练在促进肌腱-骨附着处骨再生及其相关机制中的作用。

方法

建立肌腱-骨附着处损伤模型后，通过 Micro CT 和 HE 染色验证跑步机训练对肌腱-骨愈合的影响；然后通过 TRAP 染色和细胞培养验证 CX3CL1 对破骨细胞分化的影响；最后通过生物力学测试和行为测试验证小鼠的功能恢复。

结果

跑步机训练抑制了肌腱-骨损伤后 CX3CL1 的分泌，并抑制了局部破骨细胞的分化，最终减少了骨溶解并促进了肌腱-骨愈合。

讨论

我们的研究发现了跑步机训练与 CX3CL1-C3CR1 轴之间的相互作用，为康复训练提供了一定的理论依据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/a136d10e6d1a/fimmu-14-1295163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/b24a49b11715/fimmu-14-1295163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/e61824e12235/fimmu-14-1295163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/5d4ddc758dd3/fimmu-14-1295163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/77ba3065ded0/fimmu-14-1295163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/a136d10e6d1a/fimmu-14-1295163-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/b24a49b11715/fimmu-14-1295163-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/e61824e12235/fimmu-14-1295163-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/5d4ddc758dd3/fimmu-14-1295163-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/77ba3065ded0/fimmu-14-1295163-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/85c5/10811130/a136d10e6d1a/fimmu-14-1295163-g005.jpg

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