Zhang Feiyu, Tan Yuchen, Cai Zhiyuan, An Kang, Liu Yongjie, Su Junhu
Southwest Survey and Planning Institute of National Forestry and Grassland Administration, Kunming, China.
College of Grassland Science, Key Laboratory of Grassland Ecosystem (Ministry of Education), Gansu Agricultural University, Lanzhou, China.
Front Vet Sci. 2024 Jan 12;10:1342630. doi: 10.3389/fvets.2023.1342630. eCollection 2023.
Captivity serves as the primary method for enhancing animal survival and productivity. However, the stress induced by confinement can hinder animal growth and reproduction. The administration of drugs to captive animals can effectively regulate their stress response and can also be used inartificial breeding, reproduction, and experimental animalization of wild species. The plateau zokor (), a subterranean herbivore, experiences significant stress during the captive process owing to its unique habitat.
In our study, we utilized (RA) and (AS) extracts to intervene in the stress response of plateau zokors.
Our findings demonstrated that RA and AS treatment considerably improved food intake and reduced weight loss, stress-related behavior, and stress hormone levels in plateau zokors. Furthermore, the excitatory pathway of amphetamine addition in the hypothalamus was suppressed by RA and AS treatment, acting through the and gene families. Notably, after RA treatment, the extracellular matrix-receptor interaction pathway, enriched by the gene, was significantly upregulated, potentially enhancing the immune function of captive plateau zokors.
In conclusion, our research demonstrates that RA and AS treatment can effectively alleviate the stress response of plateau zokors in captive environments. The downregulation of the excitation pathway and upregulation of the immune pathway offer valuable insights into the response and potential mechanisms of plant-based drugs in mitigating animal stress.
圈养是提高动物存活率和生产力的主要方法。然而，圈禁所带来的压力会阻碍动物的生长和繁殖。给圈养动物用药可以有效调节它们的应激反应，还可用于野生动物的人工繁育、繁殖及实验动物化。高原鼢鼠是一种地下食草动物，由于其独特的栖息地，在圈养过程中会经历显著的压力。
在我们的研究中，我们利用[具体提取物1]（RA）和[具体提取物2]（AS）提取物来干预高原鼢鼠的应激反应。
我们的研究结果表明，RA和AS处理显著改善了高原鼢鼠的食物摄入量，减少了体重减轻、应激相关行为和应激激素水平。此外，RA和AS处理通过[具体基因家族1]和[具体基因家族2]基因家族抑制了下丘脑苯丙胺添加的兴奋途径。值得注意的是，RA处理后，由[具体基因]富集的细胞外基质-受体相互作用途径显著上调，可能增强了圈养高原鼢鼠的免疫功能。
总之，我们的研究表明，RA和AS处理可以有效缓解圈养环境中高原鼢鼠的应激反应。兴奋途径的下调和免疫途径的上调为植物性药物缓解动物应激的反应及潜在机制提供了有价值的见解。
