Maldarelli Mary E, Noto Michael J
Division of Pulmonary and Critical Care Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA.
Immunometabolism (Cobham). 2024 Jan 25;6(1):e00036. doi: 10.1097/IN9.0000000000000036. eCollection 2024 Jan.
Recent advances shed light on the importance of mitochondrial metabolism in supporting essential neutrophil functions such as trafficking, NETosis, bacterial killing, and modulating inflammatory responses. Mitochondrial metabolism is now recognized to contribute to a number of lung diseases marked by neutrophilic inflammation, including bacterial pneumonia, acute lung injury, and chronic obstructive pulmonary disease. In this mini review, we provide an overview of neutrophil metabolism focusing on the role of mitochondrial programs, discuss select neutrophil effector functions that are directly influenced by mitochondrial metabolism, and present what is known about the role for mitochondrial metabolism in lung diseases marked by neutrophilic inflammation.
近期的研究进展揭示了线粒体代谢在支持中性粒细胞的重要功能（如迁移、中性粒细胞胞外诱捕网形成、细菌杀伤以及调节炎症反应）中的重要性。现在人们认识到，线粒体代谢与多种以中性粒细胞炎症为特征的肺部疾病有关，包括细菌性肺炎、急性肺损伤和慢性阻塞性肺疾病。在本综述中，我们概述了中性粒细胞代谢，重点关注线粒体程序的作用，讨论了直接受线粒体代谢影响的特定中性粒细胞效应功能，并介绍了线粒体代谢在以中性粒细胞炎症为特征的肺部疾病中的作用。
